Join Dr. Michael Foote for a session on “Genomic HER2 amplification predicts for complete clinical response in a phase II study of induction tucatinib and trastuzumab combined with chemotherapy in locally advanced #rectal #adenocarcinoma” at #AACR26. @theaacr.bsky.social

https://bit.ly/42etwHP

Tobacco smoke but not e-cigarette vapor induces epithelial barrier disruption, inflammation, and DNA damage in human Calu-3 cells - Scientific Reports Cigarette smoke is the leading cause of lung diseases including chronic bronchitis and chronic obstructive pulmonary disease (COPD). While harmful effects of cigarette smoke on lung epithelial function are well established, the consequences of inhalation of aerosols from e-cigarettes are less clear and disputed. In this study, human lung adenocarcinoma epithelial cells (Calu-3) were treated with extracts of cigarette smoke (CSE) or e-cigarette vapor (EVE) and comparatively analyzed for barrier function and integrity as well as for mRNA and protein expression of components forming the apical junctional complex (AJC). In addition, potential proinflammatory and genotoxic effects were investigated. Our results clearly demonstrate that CSE induced considerable disruption of the epithelial barrier leading to hyperpermeability and reduced protein expression of AJC proteins, especially of claudin-1. In addition, exposure of cells to CSE induced pronounced proinflammatory effects and increased DNA double strand breaks. By contrast, EVE, even if applied undiluted, neither affected functional nor structural parameters. In summary, on the basis of our results obtained with the Calu-3 in vitro model, we propose that e-cigarette vapor may exert less harmful effects on lung epithelial cells compared to cigarette smoke.

Exposure of human lung #adenocarcinoma epithelial cells (#Calu-3) to cigarette smoke extracts→ #inflammation+↑ #DNA double strand breaks. #e-cigarette vapor no effect. e-cigarette vapor may exert less harmful effects on lung #epithelial cells compared to cigarette smoke. bit.ly/4tEa3vO

Finally, two days after viral #challenge, Hif1aiKO mice showed higher infectious titers, which were rescued by exogenous IL-21 treatment. A similar effect was observed in the survival of Hif1a iKO mice in a lung #adenocarcinoma model (10/10).

Long-Term Proton Pump Inhibitor Use Not Linked to Gastric Adenocarcinoma There was no association observed between long-term proton pump inhibitor use and gastric adenocarcinoma.

Long-term #PPI use seems not to be associated with an increased risk for #gastric #adenocarcinoma.

Read More: https://bit.ly/4c7NxpC

PIK3CA Mutations in Early-Onset Appendiceal Adenocarcinoma | JCO Precision Oncology PURPOSEApproximately one in three patients with appendiceal cancer (AC) is diagnosed before age 50 years. Early-onset appendiceal cancer (EOAC) exhibits distinct clinicopathologic and demographic feat...

Mutaciones PIK3CA son más comunes en el cáncer apendicular de inicio temprano y se asocian con una peor supervivencia general, por lo que deben incorporarse en las evaluaciones pronósticas #appendiceal #adenocarcinoma ascopubs.org/doi/abs/10.1...

We're excited for @ascocancer.bsky.social #GI26! Stop by Dr. Steve Maron's poster to learn about a phase 2 trial of amivantamab for EGFR- or MET-amplified #gastroesophageal #adenocarcinoma. @mskcancercenter.bsky.social #GICancer

TODAY | 11:30 – 1 p.m. PST

Learn more: bit.ly/49cfzyr

Peripheral TERT- positive leukocytes as a biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression - Molecular Biomedicine The prognosis of early-stage lung adenocarcinoma (LUAD) worsens significantly during the progression from adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA) to invasive adenocarcinoma ...

#Research
Peripheral TERT- positive #leukocytes as a #biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression doi.org/10.1186/s435...

#LungAdenocarcinoma #LUAD #Invasive #Adenocarcinoma #Immunosuppression

A multi-center, single-arm, phase 2 trial evaluating the antitumor activity of camrelizumab + apatinib and S-1 + oxaliplatin, demonstrated safety and efficacy in patients with AFP-G/GEJ #adenocarcinoma. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Arising Mediastinal #Adenocarcinoma in A Patient With A 14 Years History of Mature #Teratoma
onlinelibrary.wiley.com/doi/10.1002/...

Rebecca Heineman, Interplay Co-Founder, Dead at 62 Rebecca Heineman, co-founder of Interplay, has died at age 62 after battling cancer. Her GoFundMe page for medical expenses will now go towards funeral costs.

Rebecca Heineman, Interplay Co-Founder, Dead at 62 totalapexgaming.com/news/rebecca...
#industrylegend #Interplay #adenocarcinoma #ContrabandEntertainment #BaldursGate

#EsophagusPathology28 #SquamousCellCarcinoma #Adenocarcinoma #EsophagealCancer #GERD #BarrettsEsophagus #PlummerVinsonSyndrome #EosinophilicEsophagitis #DiffuseEsophagealSpasm #MalloryWeissSyndrome #BoerhaaveSyndrome #Dysphagia #UpperGIBleed #PathologyNotes #MedicalEducation #MedStudy #USMLE #NEETPG #FMGE #InstaMed #DrPrkashMishra

#EsophagusPathology28
#SquamousCellCarcinoma #Adenocarcinoma #EsophagealCancer #GERD #BarrettsEsophagus #PlummerVinsonSyndrome #EosinophilicEsophagitis #DiffuseEsophagealSpasm #MalloryWeissSyndrome #BoerhaaveSyndrome #Dysphagia #UpperGIBleed #PathologyNotes #MedicalEducation #MedStudy #USMLE #NEETPG

Caso clínico: informe de seguimiento sobre el taponamiento omental y el tratamiento farmacológico para el adenocarcinoma de próstata canino Caso clínico: informe de seguimiento sobre el taponamiento omental y el tratamiento farmacológico para el adenocarcinoma de próstata canino

#axónvet #informaciónveterinaria #saludanimal #adenocarcinoma #perro #próstata 

Yale Study Sheds Light on Cellular Resistance to Osimertinib in Adenocarcinoma Some lung cancers manage to overcome a targeted drug therapy despite it showing initial success. Yale researchers have now discovered a molecular-level

A Yale study finds the protein #METTL7A triggers early resistance to #osimertinib by reshaping DNA architecture. Targeting METTL7A could help block resistance before it starts. #lungcancer #adenocarcinoma
➡️ yalecancercenter.org/news-article...

Neoadjuvant #Selpercatinib for Stage IIIA Primary Pulmonary #Adenocarcinoma With RET Fusion: A Case Report
onlinelibrary.wiley.com/doi/10.1002/...

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

🧪 🔎 Clinicopathological characteristics and prognosis of #cervical #adenocarcinoma across diverse histological subtypes by Xiaowan Guo et al

journals.sagepub.com/share/ZUU92B...

Lung #Adenocarcinoma Diagnosed in a Nodule After Initial Spontaneous Regression in Size
onlinelibrary.wiley.com/doi/10.1002/...

Diffuse Pneumonic Type Lepidic #Adenocarcinoma (DP-LPA)
onlinelibrary.wiley.com/doi/10.1002/...

This study shows that #camrelizumab plus #apatinib with SOX, followed by maintenance treatment, achieved favorable survival outcomes, highlighting this combination as a promising treatment option in AFP-G/GEJ #adenocarcinoma. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Tobacco smoke alters the trajectory of lung adenocarcinoma evolution via effects on somatic selection and epistasis Background Tobacco smoke is a known mutagen. However, its physiological effects on the lung may also influence the somatic selective pressures acting on mutations, further shaping cancer evolution. Th...

A study led by @jeffreytownsend.bsky.social reveals #tobacco alters lung #adenocarcinoma evolution: smokers’ tumors favor KRAS/KEAP1/STK11, never-smokers’ favor EGFR/PIK3CA—revealing distinct treatment vulnerabilities.
biorxiv.org/content/10.1...
@toomuchvitamink.bsky.social

#Pembrolizumab-Induced Severe #Pneumonitis in a Patient With Lung #Adenocarcinoma After Umbilical Cord Blood Transplantation: A Case Report
onlinelibrary.wiley.com/doi/10.1002/...

Fig. 3. Summed dose distribution of the two treatment plans Sum of the dose from external beam photon radiotherapy and carbon ion radiotherapy, expressed in EQD2.

Clear cell #adenocarcinoma of the uterine cervix is a rare and aggressive subtype of #cervicalcancer, typically resistant to conventional #RT. Read a case report in press with IJPT that suggests a #CIRT boost can achieve long-term local control: www.sciencedirect.com/science/arti... #cancerresearch

🩺 Cancer Diary: When the Fight Isn’t Over News about MSI Press authors; Excerpts from MSI Press authors' books; Carl's Cancer Compendium information; tips for authors

Today's blog post, the next in the #Cancer Diary series, focuses on cancers that continue to spread: "When the Fight Isn't Over"

msipressblog.blogspot.com/2025/08/canc...

#breastcancer #skincancer #melanoma #adenocarcinoma

Donate to Support Courtney's Fight at Mayo Clinic, organized by Courtney Leigh Fighting for My Life After 10 Years of Illness – Please Help Hi, my nam… Courtney Leigh needs your support for Support Courtney's Fight at Mayo Clinic

gofund.me/362fc650

I need your help friends. Any amount helps. Please feel free to share the link, it helps more than you know. #cancersucks #pacemakersurgery
#pacemakerpatient #gastrointestinalcancer #adenocarcinoma #rarecancer #mayoclinic #healthcrisis #donateforcare #rarecancerawareness

Going for a CT scan of my lungs this morning. It's the first since my NSCLC surgery in January. We're monitoring the *new* spot in the other lung.

#scanxiety
#ThanksCancer
#cansky
#adenocarcinoma

Next Generation Sequencing 🧬🔬 labs allows cost-effective NGS molecular profiling of the majority of lung #adenocarcinoma Pts👇

Regional Deliberation:
✔️ established diagnostic workflow
✔️ formalized network of pathology lab
✔️ introduced a reimbursement code

journals.sagepub.com/doi/10.1177/...

Rare Case of #Tongue #Metastasis From #Lung #Adenocarcinoma, With White Coating Appearance
onlinelibrary.wiley.com/doi/10.1002/...

Successful #Tepotinib Treatment in MET Exon 14 Skipping Mutation-Positive Lung #Adenocarcinoma With Idiopathic Pulmonary Fibrosis Through #Nintedanib Combination
onlinelibrary.wiley.com/doi/10.1002/...
#IPF

MATTERHORN Trial on dFLOT for G/GEJ: ESMO GI 2025: The MATTERHORN trial at ESMO GI 2025 showed that durvalumab plus FLOT improves event-free survival in resectable G/GEJ adenocarcinoma.

ESMO GI 2025 Highlights: MATTERHORN Trial on Durvalumab + FLOT in Resectable G/GEJ Adenocarcinoma
@myesmo.bsky.social

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ESMO #ESMOGI25 #MATTERHORN #Adenocarcinoma

📢Welcome to read: #Chromosome X Open Reading Frame 38 (#CXorf38) Is a #Tumor Suppressor and Potential Prognostic #Biomarker in Lung #Adenocarcinoma: The First Characterization, by Rui Yan et al.
See more at: 🔗mdpi.com/2227-7382/13/2/22
#proteomics #proteomes #proteoforms #cancer #protein #OpenAccess

Okay sooooooooo

High dose steroid-induced panic/rage attacks are a thing that no one adequately prepared me for.

Thank you, helpful pharmacist, for making me aware of this.

Thanks, dexamethasone, for helping my lungs but hurting my already fragile psyche.

4mg BID= Hades.

#adenocarcinoma