The April issue of Transplantation features cutting-edge studies presented at the #WTC2025 with real clinical impact, from viruses to vaccines, offering new insights to improve care for transplant recipients. #TXPforAll #Transplantation tinyurl.com/3xxbakmu

Over 20 years of data show that DCD islets perform as well as DBD islets—with a trend toward better diabetes reversal. A promising way to increase donor availability for type 1 diabetes treatment. #TXPforall #Transplantation tinyurl.com/4p255ryk

This study shows persistent socioeconomic disparities in England—affecting access, donor type, and outcomes—while Northern Ireland shows more equitable access. Healthcare delivery models clearly matter! #TXPforall #Transplantation tinyurl.com/mr7aj24c

Can alkaline phosphatase (ALP) protect donor kidneys? In a porcine model, adding ALP during preservation improved energy status and reduced metabolic stress after reperfusion. Promising strategy to reduce delayed graft function #TXPforAll #Transplantation tinyurl.com/muyxpww6

❤️ This study by Rosethal et al. shows that clinical follow-up + echocardiography (TDI) may safely monitor rejection, with high graft survival and low detection yield from routine biopsies. Less invasive care looks promising! #TXPforAll #Transplantation tinyurl.com/cnwc64wr

This review by Cantarelli et al. highlights how EPO promotes tolerance, dampens inflammation, and shapes T cells and macrophages in kidney disease and #transplantation. #TXPforAll #Immunology tinyurl.com/5x79n7b5

Milestone reached! Our community has grown to 11,000 followers on X/Twitter. Researchers, clinicians, & transplant enthusiasts around the world who share, discuss, & advance the science of transplantation together. Thank you for being part of this growing community! #TXPforAll

Does the logistics of normothermic machine perfusion matter in liver transplantation from donation after circulatory death donors is discussed in this paper by Alderete et al. #TXPforAll #Transplantation #OpenAccess tinyurl.com/4zjt47ae

#TBT to this week's featured top downloaded paper from 2024: Efficacy and Safety of Bleselumab in Preventing the Recurrence of Primary Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Phase 2a, Randomized, Multicenter Study #TXPforAll tinyurl.com/yc4munav

The BEAT-BK Trial is putting Intravenous Immunoglobulin to the test as an add-on strategy to control BK polyomavirus in kidney transplant recipients aiming to fight the virus without risking rejection. #TXPforAll #Transplantation #OpenAccess tinyurl.com/4nhvvp4z

The paper by Gerckens et al. discusses whether we can improve risk prediction after lung transplantation by personalizing lung function assessment #TXPforAll #LungTransplantation tinyurl.com/yc92w5yf

Can we better predict viability of DCD donor hearts? This study by Saemann et al. study shows that combining laser Doppler perfusion shifts with venous lactate during ex vivo blood perfusion can accurately predict post-transplant heart function. #TXPforAll tinyurl.com/48wbkbtv

Frailty in kidney transplant candidates depends heavily on how you measure it, and current tools don’t agree. It’s time for a standardized approach to make evaluation and listing fairer and more consistent. #TXPforAll #Transplantation tinyurl.com/42y8pw63

Freely downloadable paper alert! A new study dives into the vibrant #transplant community on Reddit, analyzing 1000 posts from r/transplant. The focus? How patients share experiences and seek support around solid organ transplants. #TXPforAll tinyurl.com/3k6kwj8w

At the 2025 World Transplant Congress, experts gathered to discuss the future of #LungTransplantation, from cutting-edge research to life-saving solutions for advanced pulmonary disease. @stephenjmdphd #TXPforAll #Transplantation tinyurl.com/36hm5yja

Study involving pigs, lungs cooled to −21°C performed significantly better, showing stronger oxygenation, lower pressures and healthier cells during perfusion. Sometimes, the breakthrough is as simple as keeping it cool! #TXPforAll tinyurl.com/3mv7dwey

Rethinking how we assess donor kidney viability. Ex vivo machine perfusion allows dynamic organ evaluation but traditional in vivo biomarkers fall short in this setting. #Transplantation #TXPforAll #Biomarker tinyurl.com/5bjkrvza

This review compares global simulated allocation models (SAMs). These models have been instrumental in predicting the real-world impact of new transplant rules governing the allocation of kidneys, livers and thoracic organs in the US and beyond. #TXPforAll tinyurl.com/7ess6bxn

Not all HLA-DQ mismatches are equal 🧬Here, the authors pinpoint the amino acids that spark harmful antibodies—helping predict high-risk transplants and improve long-term outcomes. #TXPforAll #immunology #transplantation tinyurl.com/3whj5wv2

🫁This study by Alavi et al. shows that static cold storage (SCS) increases Von Willebrand factor (VWF) expression in lung microvascular cells — potentially raising the risk of thrombosis after transplant. #TXPforAll #LungTransplantation #OpenAccess tinyurl.com/y6a5r2cd

This paper by Leyder et al. shows that 🫁 lung transplants play by different immune rules. CD8+ T cells and even eosinophils may promote tolerance; not rejection! #TXPforAll #Transplantation #Immunology tinyurl.com/ax5zawcw

New hope for recurrent FSGS after kidney transplant: Targeting B cells and plasma cells with rituximab + daratumumab led to remission and improved kidney function in patients who hadn’t responded to standard therapies. #TXPforAll tinyurl.com/3nxrupcs

This study explored the use of digital health tools, specifically accelerometers and continuous glucose monitors (CGMs), in kidney transplant candidates over 50 years old. #TXPforAll #Transplantation #OpenAccess tinyurl.com/y5sdwhat

Safer, more durable kidney transplants were the focus at #WTC2025. Discussions centered on personalized immunosuppression, innovative trial designs, managing side effects, and improving adherence through patient education. #TXPforAll #Immunosuppression tinyurl.com/3czwpkmb

The blood tells the story. 🫀Transcriptomic profiling reveals immune signatures of acute cellular rejection and points to new blood-based predictors in heart transplantation. #TXPforAll #Biomarker #Transplantation tinyurl.com/cc8trbj4

This paper, which is available to download for free, notes that empowered patient and family volunteers are essential for effective and equitable transplant policies within the OPTN. #TXPforAll #Transplantation tinyurl.com/b9bh75w2

Beyond the biopsy? 🩺Monitoring dd-cfDNA early after kidney transplant may help identify patients at risk for rejection and declining graft function—offering actionable prognostic insight. #TXPforAll #Biomarker #Transplantation tinyurl.com/5brs983z

#TBT to this week's featured top downloaded paper from 2022: Advances in Kidney Preservation Techniques and Their Application in Clinical Practice #TXPforAll #Transplantation #Med tinyurl.com/4syckhzw

New study links the lung bacteriome to transplant outcomes. Species-level profiling of BAL samples identified lower Corynebacterium and higher oral anaerobes as predictors of acute cellular rejection after lung transplantation. #TXPforAll #Transplantation tinyurl.com/yc2wyf2t

A potential breakthrough for recurrent FSGS after kidney transplant 🩺. Dual B cell and plasma cell targeting induced remission and improved kidney function in patients unresponsive to standard therapies. #TXPforAll #Transplantation #Immunosuppression tinyurl.com/mr37ukc4