#PRDX4 disrupts #PTEN homodimerization to activate AKT/NF‑κB signaling, driving #alveolar #macrophage activation and fibrosis, and emerges as a novel upstream regulator of PTEN and promising target for #PulmonaryFibrosis and #silicosis.
#OpenAccess in #STTT: doi.org/10.1038/s413...
αCGRP deficiency aggravates #pulmonary #fibrosis by promoting #senescence in #alveolar type 2 #cells
#Genes & #immunity @springernature.com
www.nature.com/articles/s41...
Day 2 of #EMDS2025 starts with a beautiful talk about lung tissue resident #alveolar #macrophage identity and the influence of #IL-33 on this, by Stijn Verwaerde from BART Lambrecht’s lab.
Super happy to be part of this initiative! Together with @agvazquez.bsky.social we will be working on the interaction between #Alveolar #Macrophages and #Epithelial #Cells in the #lung
Still time left to apply!! www.linkedin.com/posts/elvira...
#immunosky
In this Methods and Techniques article, Michele Girardi (@thelundquist.bsky.social) et al. show how breath-by-breath measurement of #alveolar gas exchange must preserve mass balance and conform to a #physiological definition of a #breath
📜 buff.ly/TJDMp8V
ONLINE COVER: Lymph Nodes Get a Remodel. Fibroblastic reticular cells (FRCs) are stromal cells that coordinate structural remodeling and adaptive immune responses in the lymph node. Using single-cell transcriptomics and high-resolution microscopy, Lütge et al. comprehensively characterized the stromal cell landscape of human lymph nodes during quiescence and inflammation. Inflammation drove lymph node remodeling including the expansion of peptidase inhibitor 16 (PI16)+ FRCs in macrophage-rich perivascular niches. This month’s cover image shows an inflamed human lymph node that has undergone expansion of podoplanin+ FRCs (purple) near alpha smooth muscle actin (ACTA2)+ vascular smooth muscle cells (green) to support immune cell infiltration and BCL6+ germinal center B cell (orange) activity. Credit: Lisa Kurz/Kantonsspital St. Gallen
The May issue of #Science #Immunology is out now!
This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes!
science.org/toc/sciimmunol/10/107
Speaker Highlight - Bart Lambrecht
Interested in #alveolar #macrophages (AMs)? Then do not miss Bart Lambrecht from @viblifesciences.bsky.social at EMDS2025 - he'll discuss recent work showing how AMs can become multi-nucleated giant cells!
@britsocimm.bsky.social
Photo by Sam Sills
#Medsky🧪 #IDSky #ImmunoSky #publichealth From all the evidences Severe #Covid causes Pneumonia & 🫁 tissue damage. This leads to sub performance in the pulmonary gaseous exchange by the #alveolar cells causing #hypoxia associated with clinical severities/mortality.
