Function: #efferocytosis gets a boost. IFN-I increases #apoptotic cell uptake by macrophages. This requires #ISG15; #OMA1 mitochondrial protease is dispensable for this step. ISG15 deficiency shows impaired clearance of #apoptotic cells in vivo in thymic or peritoneal challenges. #Immunosky

Excessive #inflammation?
We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful...
#immunosky

Have a look at our latest preprint, "Nuclear plasticity regulates macrophage phagocytic capacity in vivo".

#apoptoticbodies #efferocytosis #nucleus #Drosophila #macrophages #mechanoresponse #InVivo #LiveImaging

doi.org/10.64898/202...

This #STTT study identified SIK3 as an inhibitor of macrophage #Efferocytosis, demonstrating that SIK inhibition promotes M2 polarization & Treg differentiation to alleviate #SynovialInflammation & bone destruction in RA.

#OpenAccess: doi.org/10.1038/s413...

Efferocytosis in Health and Disease Efferocytosis in health and disease. Efferocytosis integrates apoptotic cell recognition, engulfment, digestion, and reprogramming to link cell clearance with tissue repair. Molecular checkpoints bal...

#Review in #MedComm
Efferocytosis in Health and Disease doi.org/10.1002/mco2...

#ApoptoticCellClearance #CD47 #TAMreceptor #efferocytosis #ImmunometabolicRewiring

#EndothelialCell #MerTK #Efferocytosis #Atherosclerosis

EC MerTK KO🐭+ AAV8-PCSK9 + #HighFatDiet 2-mo
👉⏫lesion burden
👉⏫NADPH oxidase
👉⏫inflamm cytokines

Aortic Arch lesion #Proteomics➡️
⏫TGFβ HIF1α Wnt3a IL2
⏬LARP1 NAMPT TEAD1

Zufeng Ding lab #RedoxBiol 2025
www.sciencedirect.com/science/arti...

This new review outlines the role of cell-mediated #Efferocytosis in clearing #Neutrophils and M1 macrophages, links to M2 polarization, and identifies molecular pathways that serve as targets to improve #TissueRepair. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis

This article summarizes the molecular and #CellularMechanisms underlying the initiation and progression of #Atherosclerosis, and reviews its current therapeutic strategies, along with future challenges and improvements. #nanoparticles #efferocytosis #medsky

link.springer.com/article/10.1...

TNF switches homeostatic efferocytosis to lytic caspase-8–dependent pyroptosis and IL-1β maturation Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production.

New study reveals that tumor necrosis factor (TNF) can reprogram macrophage #efferocytosis from silent to pro-inflammatory during #sepsis and systemic inflammation.
Read in Science Immunology: scim.ag/45Yvj6Y

ONLINE COVER: Lymph Nodes Get a Remodel. Fibroblastic reticular cells (FRCs) are stromal cells that coordinate structural remodeling and adaptive immune responses in the lymph node. Using single-cell transcriptomics and high-resolution microscopy, Lütge et al. comprehensively characterized the stromal cell landscape of human lymph nodes during quiescence and inflammation. Inflammation drove lymph node remodeling including the expansion of peptidase inhibitor 16 (PI16)+ FRCs in macrophage-rich perivascular niches. This month’s cover image shows an inflamed human lymph node that has undergone expansion of podoplanin+ FRCs (purple) near alpha smooth muscle actin (ACTA2)+ vascular smooth muscle cells (green) to support immune cell infiltration and BCL6+ germinal center B cell (orange) activity. Credit: Lisa Kurz/Kantonsspital St. Gallen

The May issue of #Science #Immunology is out now!

This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes!

science.org/toc/sciimmunol/10/107

Dissecting inflammation in the immunemetabolomic era - Cellular and Molecular Life Sciences The role of immune metabolism, specific metabolites and cell-intrinsic and -extrinsic metabolic states across the time course of an inflammatory response are emerging knowledge. Targeted and untargete...

Check out our new review discussing novel immunometabolic mechanisms underlying inflammation, metabolomic techniques and potential metabolite biomarkers of chronic inflammatory disease!

Special focus is on #efferocytosis #IL-10 and #trainedimmunity

link.springer.com/article/10.1...

#Medsky🧪 #immunosky #neurosky #pharmasky #Publichealth Continual #efferocytosis, the process by which macrophages perform repeated rounds of ingesting damaged or dead cells, is important for resolving inflammation and for removing damaged tissue.

The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis Macrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.

#ImmunoSky #MedSky

#drugrepurposing

#Inflammation: "Time to halt the #Dopamine rush"

An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis

Now @science.org signaling

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

Excellent #immunometabolism concept presented by Garaude lab @univbordeaux.bsky.social in @nature.com. #macrophage #nutrient use of dead bacteria via #phagocysosis drives distinct #metabolism pathways. #mTOR rears its head of course. #efferocytosis should be up next!
www.nature.com/articles/s41...

Revealing the potential of #efferocytosis in mitigating #stroke-induced #brain damage
www.eurekalert.org/news-release...

Where are all the big drinkers🍺 and big eaters? I've created a starter pack to track down the #macropinocytosis, #phagocytosis, and #efferocytosis researchers on Bluesky. Who else is here? Please let me know and I'll add you/them! 🧪

For all things #efferocytosis merged with #infection this is the project for you!

Huge thank you to BSI for the funding to support my project! Very excited for our work on #efferocytosis to take off! @mtrost.bsky.social

My continued biomedical education

Specialized Pro-resolving Mediators in #VascularInflammation & #AtheroscleroticCardiovascularDisease

Resolvin
Protectin
Maresin

#EndothelialCell + #Neutrophil in SPM synthesis

⏫Mφ #efferocytosis #MERTK #FAO

#NatRevCardiol 2024
www.nature.com/articles/s41...