#EndothelialCell #MerTK #Efferocytosis #Atherosclerosis

EC MerTK KO🐭+ AAV8-PCSK9 + #HighFatDiet 2-mo
👉⏫lesion burden
👉⏫NADPH oxidase
👉⏫inflamm cytokines

Aortic Arch lesion #Proteomics➡️
⏫TGFβ HIF1α Wnt3a IL2
⏬LARP1 NAMPT TEAD1

Zufeng Ding lab #RedoxBiol 2025
www.sciencedirect.com/science/arti...

The C-Mer Gene Is Induced by Epstein-Barr Virus Immediate-Early Protein BRLF1 BRLF1 (R) is one of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent to the lytic form of viral replication. In this report, we show that R induces express...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Modulation of the C-mer signal transduction cascade by a variety of different approaches did not alter the ability of R to induce lytic EBV gene transcription."

"Therefore, C-mer activation may be important for some other aspect of lytic EBV infection." #MERTK

The C-Mer Gene Is Induced by Epstein-Barr Virus Immediate-Early Protein BRLF1 BRLF1 (R) is one of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent to the lytic form of viral replication. In this report, we show that R induces express...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"C-mer is required for phagocytosis of apoptotic debris by monocytes/macrophages and retinal pigment epithelial cells and is capable of producing an antiapoptotic signal." #MERTK

The C-Mer Gene Is Induced by Epstein-Barr Virus Immediate-Early Protein BRLF1 BRLF1 (R) is one of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent to the lytic form of viral replication. In this report, we show that R induces express...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Oral hairy leukoplakia tongue tissue, which contains the lytic form of EBV replication, also has enhanced C-mer expression."

"C-mer is a receptor tyrosine kinase activated by the ligand Gas6." #MERTK

The C-Mer Gene Is Induced by Epstein-Barr Virus Immediate-Early Protein BRLF1 BRLF1 (R) is one of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent to the lytic form of viral replication. In this report, we show that R induces express...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"C-mer expression was detected in lymphoblastoid cells immortalized with wild-type EBV but not in lymphoblastoid cells immortalized with an EBV that had BRLF1 deleted." #MERTK

The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1 - PubMed BRLF1 (R) is one of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent to the lytic form of viral replication. In this report, we show that R induces express...

The C-mer ( #MERTK) gene is induced by Epstein-Barr virus immediate-early protein BRLF1 #EBV #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/15479819/

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart A system of macrophages in the heart supports cardiomyocyte health by phagocytosing exopher particles ejected from cardiomyocytes that contain defective mitochondria, among other cellular contents.

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart #MerTK #MECFS #LongCovid

www.cell.com/cell/fulltex...

My continued biomedical education

Specialized Pro-resolving Mediators in #VascularInflammation & #AtheroscleroticCardiovascularDisease

Resolvin
Protectin
Maresin

#EndothelialCell + #Neutrophil in SPM synthesis

⏫Mφ #efferocytosis #MERTK #FAO

#NatRevCardiol 2024
www.nature.com/articles/s41...