🎥 Highlights from yesterday's VPD-HLRI Monthly Seminar! Great talks by Prof. Jason Gill from @uofglasgow.bsky.social and our very own Prof. Murray Clarke.
Thanks to our speakers and attendees!
#HLRI #MetabolicHealth #VascularInflammation @cambridgeuni.bsky.social
@murrayclarkelab.bsky.social
Hyperglycemia-YAP cascade in diabetic #VascularInflammation, likely both arterial #EndothelialCell & #SmoothMuscleCell
db/db mice
This time, TAZ seems not to be responding to #HighGlucose/#DisturbedFlow
Marco Meloni lab #FrontPhysiol 2021
www.frontiersin.org/journals/phy...
An #OscillatoryShearStress -α5β1 integrin-ABL1-YAP cascade in #EndothelialCell promotes #VascularInflammation & Apoe-/-🐭#Atherosclerosis
Elevated p-ABL1 Tyr412 & p-YAP Tyr357 on athero-prone🐭aortic endothelium &👤athero-lesional endothelium
#JCI 2019
www.jci.org/articles/vie...
My continued biomedical education
Specialized Pro-resolving Mediators in #VascularInflammation & #AtheroscleroticCardiovascularDisease
Resolvin
Protectin
Maresin
#EndothelialCell + #Neutrophil in SPM synthesis
⏫Mφ #efferocytosis #MERTK #FAO
#NatRevCardiol 2024
www.nature.com/articles/s41...
ApoB #AntiSenseOligo + low-fat diet for 12 wks alleviates #VascularInflammation in established🐭#Atherosclerosis
EC invagination+focal loss in regressing plaque😎 (#EndMT at sub-cap level)
⏫contractile #FibrousCap SMC; ⏬Fibromyocyte & Chondromyocyte
#NatureCVR 2024
www.nature.com/articles/s44...
Enhancer-associated #LongNonCodingRNA #Atherosclerosis
PSMB8-AS1⏫promixal gene transcription of PSMB9 in #EndothelialCell->
Zeb1->
VCAM1/ICAM1->
#VascularInflammation #Atherosclerosis
Serum lipids also regulated by PSMB8-AS1
#CircRes 2023
www.ahajournals.org/doi/10.1161/...
Sox10, a central hub for Mφ-like transdifferentiation of #SmoothMuscleCell #VascularInflammation #Pyropotosis
PI3K-Akt->
phospho-Sox10->
TNFα-dependent Sox10 lactylation->
pro-inflam; pro-death
RGS5⏬PI3K-Sox10 axis
F Zhang, M Han lab Cell Reports 2023
www.sciencedirect.com/science/arti...
