An #OscillatoryShearStress -α5β1 integrin-ABL1-YAP cascade in #EndothelialCell promotes #VascularInflammation & Apoe-/-🐭#Atherosclerosis

Elevated p-ABL1 Tyr412 & p-YAP Tyr357 on athero-prone🐭aortic endothelium &👤athero-lesional endothelium

#JCI 2019
www.jci.org/articles/vie...

#EndothelialCell MERTK (Efferocytosis receptor) is suppressed by #OscillatoryShearStress

MERTK KO🐭exhibit aggravated #Atherosclerosis
+accumulated apoptotic cells, mainly at intima

But how much is contributed by defect EC-mediated efferocytosis?🧐

#THNO 2024
www.thno.org/v14p2427.htm