Adult🐭Lung Veins Branch & serve as cellular sources of general capillary #EndothelialCell & Aerocyte

Upon🫁injury Not postnatal development

#SciArt

Slc6a2-CreERT2 labels veinous endothelium in🐭🫁but not other organs

@vaughandy.bsky.social #NatureCVR 2024
www.nature.com/articles/s44...

SM α-actin can translocate into nuclei & promote transcription of #SmoothMuscleCell contractile genes😎
SM α-actin occupies the CArG boxes, also KLF4 gene👈

ACTA2 R179C
ACTA2 R179H #SmoothMuscleDysfunctionSyndrome
⏬SMC Contractile genes

#NatureCVR 2023
www.ncbi.nlm.nih.gov/pmc/articles...

Mechanotransduction for High #ShearStress (40 dyn/cm2) in #EndothelialCell

Shear-KLF2-BMPER⬇️EC BMP-SMAD1/5 signaling➡️
⏫Carotid/Skeletal muscle arterial outward remodeling

BMP9/10 antibody⏫ischemic limb reperfusion in diabetic🐭

Martin Schwartz lab #NatureCVR 2024
www.nature.com/articles/s44...

Are there aorta-resident macrophages?

1⃣LYVE1+MMP9+ resident Mφ engages #Hyaluronan to degrade collagen fibrils, in adventitia+media
#ImmunityCP 2018
www.sciencedirect.com/science/arti...
2⃣MacAIR: Flow-sensing, anti-thrombotic aortic intima-resident Mφ
#NatureCVR 2022
www.nature.com/articles/s44...

MerTK+ Cardiac-resident Macrophages protect against🐭🫀#IschemiaReperfusionInjury

GAS6-ATF3 cascade
⏫IFNα/β signaling
⏬apoptosis
⏫proliferation
in MerTK+ Mφ
Pro-angiogenic IGF1 paracrine of MerTTK+ Mφ😎

Plasma GAS6
➖corr MACEs
in👤#AcuteCoronarySyndrome

#NatureCVR 2024
www.nature.com/articles/s44...

TREM2 as a positive regulator of Macrophage #FoamCell mitochondria, survival & efferocytosis under hypercholesterolemia

Hematopoietic TREM2 KO⏫#NecroticCore formation in early (8~12 wk) #Atherosclerosis in Ldlr-/-🐭
w/o altering lesion or Mφ burden

#NatureCVR 2024
www.nature.com/articles/s44...

#CardiacFibroblast/#Cardiomyocyte-derived BMP4 alleviates T-cell-driven #AutoimmuneMyocarditis
TCR-M🐭

Inflammatory Cxcl9+Ccl9+H2-A2+ fibroblast subset

Grem1/2 (BMP inhibitor) blockade (Ab 14-D10-2)⏬Mortality
w/o changing cardiotoxic CD4+ T cells

#NatureCVR 2024
www.nature.com/articles/s44...

ApoB #AntiSenseOligo + low-fat diet for 12 wks alleviates #VascularInflammation in established🐭#Atherosclerosis

EC invagination+focal loss in regressing plaque😎 (#EndMT at sub-cap level)
⏫contractile #FibrousCap SMC; ⏬Fibromyocyte & Chondromyocyte

#NatureCVR 2024
www.nature.com/articles/s44...