ibidi Know How: Culturing cells on a 3D gel matrix with controlled #flow🥼
The µ-Slide I Luer 3D allows you to culture cells on a 3D gel matrix while applying #defined and #reproducible #shearstress through a simple channel on top.
📚 zurl.co/Va3gt
#3Dcellculture
Study of flow-mediated dilation after acute passive #heating by hot-water immersion reports confounding role of altered branchial #artery #shearstress and baseline #vasodilation.
doi.org/10.14814/phy...
#Thermal Physiology #Cardiovascular
Natural medicines target tumor vascular microenvironment to inhibit tumor
This review summarizes the angiogenesis of the #tumormicroenvironment, highlights natural medicines targeting the vascular microenvironment, and explores how tumor cells and #vasculature respond to different fluid #ShearStress levels. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
So excited to present our first data today @ AIM center seminar. Hopefully more coming soon #ShearStress #Kidney #ATG
@womeninautophagy.bsky.social
@membramics-lab.bsky.social
Mechanotransduction for High #ShearStress (40 dyn/cm2) in #EndothelialCell
Shear-KLF2-BMPER⬇️EC BMP-SMAD1/5 signaling➡️
⏫Carotid/Skeletal muscle arterial outward remodeling
BMP9/10 antibody⏫ischemic limb reperfusion in diabetic🐭
Martin Schwartz lab #NatureCVR 2024
www.nature.com/articles/s44...
#SmoothMuscleCell senses Interstitial Fluid #ShearStress #Atherosclerosis
Normal human artery
0.06-0.6 dyne/cm2
Atherosclerotic intima
0.33-3.27 dyne/cm2
◀️ ⏫endothelial/intimal/medial Porosity (How is this measured?)
EGFR-ERK1/2-KLF5 mechanotransducing cascade
IJBS 2024
www.ijbs.com/v20p2727.htm
