SM α-actin can translocate into nuclei & promote transcription of #SmoothMuscleCell contractile genes😎
SM α-actin occupies the CArG boxes, also KLF4 gene👈

ACTA2 R179C
ACTA2 R179H #SmoothMuscleDysfunctionSyndrome
⏬SMC Contractile genes

#NatureCVR 2023
www.ncbi.nlm.nih.gov/pmc/articles...