Global #GasderminD/GSDMD KO reduced #ThoracicAorticDissecition #IntramuralHematoma He in🐭+BAPN (0.2%) +locally applied Elastase

Which cell types in dissected🐭👤aortas undergo #Pyropotosis? #Inflammasome activity? Or GSDMD➡️other modes of death

bioRxiv 2024
www.biorxiv.org/content/10.1...

Sox10, a central hub for Mφ-like transdifferentiation of #SmoothMuscleCell #VascularInflammation #Pyropotosis

PI3K-Akt->
phospho-Sox10->
TNFα-dependent Sox10 lactylation->
pro-inflam; pro-death

RGS5⏬PI3K-Sox10 axis

F Zhang, M Han lab Cell Reports 2023
www.sciencedirect.com/science/arti...