🩸Additional facts about disease biology & pathogenesis in Chronic Myelomonocytic Leukemia

#CMML #Hematology #Leukemia #HemeOnc #MedicalEducation #HematologyEducation #MyeloidBias #SRSF2 #ASXL1 #RAS #Inflammasome #NLRP3 #Cytokines #IL1beta #IL18 #MedEd #HEMEHUB

Lactic acid drives #NLRP3 #inflammasome activation and caspase-1–like cytokine cleavage via intracellular acidification

www.nature.com/articles/s41... #OpenAccess #immunology

Glibenclamide attenuates neuronal #pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice

www.sciencedirect.com/science/arti... #OpenAccess #inflammasome #inflammation #immunology #ImmunoSky #MedSky

New mechanistic insights on an old but fundamental mystery in innate immunity: how the #NLRP3 #inflammasome senses efflux of intracellular potassium ions - check out our new #biorxiv #preprint👇here: www.biorxiv.org/content/10.6...

That’s such a nice visualization of the #inflammasome pathway! Thanks for sharing!

Neutrophils and the NLRP3 inflammasome: a tale of proteases, kinases, and inflammation Cell type–specific mechanisms modulate Nod-like receptor family pyrin domain containing 3 inflammasome activation in macrophages and neutrophils, shaping i

Interested in the #NLRP3 #inflammasome in #neutrophils? Check out our recent review on this topic...: doi.org/10.1093/jleu...

Neutrophils and the NLRP3 inflammasome: a tale of proteases, kinases, and inflammation Cell type–specific mechanisms modulate Nod-like receptor family pyrin domain containing 3 inflammasome activation in macrophages and neutrophils, shaping i

"#Neutrophils and the #NLRP3 #Inflammasome: a tale of #Proteases, #Kinases, and #Inflammation" - read the new Review by Vinicius Leal @uspoficial.bsky.social & Alexander Weber @unituebingen.bsky.social

Broad-spectrum nucleocapsid-targeting #aptamer NApt8-3 blocks N protein–NLRP3 #inflammasome signaling to suppress #coronavirus inflammation; its trivalent chimera circSASON enhances delivery, reducing #SARSCoV2 replication & lung inflammation in mice.

#STTT: doi.org/10.1038/s413...

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

#MysterySolved! Fantastic @cp-immunity.bsky.social by @brozlab.bsky.social, Began &co showing that GBP1 is essential for non-canonical #inflammasome activation during infections & acts as a mechanoenzime that fragments LPS micelles allowing Caspase-4 activity! www.sciencedirect.com/science/arti...

#PulsedElectroMagneticFields inhibit #NLRP3 #inflammasome activation, reduce endothelial inflammation and #pyroptosis, restore mitochondrial function via TRPV4 regulation, and delay #atherosclerosis progression, unveiling a mechanobiological pathway.

#STTT: doi.org/10.1038/s413...

IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella - EMBO Reports IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...

IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...

Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!

TKI-mediated inhibition of NLRP1 inflammasome restores erythropoiesis in DBA syndrome - EMBO Molecular Medicine Diamond-Blackfan anemia syndrome (DBAS) is marked by defective erythropoiesis caused by impaired ribosome biogenesis and aberrant signaling. Here, we investigate how ribosomal stress-induced activatio...

TKI-mediated inhibition of NLRP1 #inflammasome restores #erythropoiesis in Diamond-Blackfan anemia syndrome 👉 doi.org/10.1038/s443...

By J. Lozano-Gil, A. Martínez-López, S. Tyrkalska, V. Mulero & colleagues @ciberisciii.bsky.social & @um.es

Crosstalk between NLRP3 Signaling and Histone Deacetylases in Inflammasome-Driven Diseases The NLRP3 inflammasome is a validated therapeutic target in inflammatory, metabolic, and neurodegenerative diseases. Epigenetic regulators, particularly histone deacetylases (HDACs), have emerged as key modulators of inflammasome priming and activation. Recent advances in medicinal chemistry have provided new chemical modalities for the mechanistic interrogation and the potential therapeutic modulation of NLRP3 signaling. This Perspective dissects the mechanistic interface between HDAC-dependent epigenetic control and NLRP3 signaling and highlights emerging chemical tools, including isoform-selective inhibitors and targeted protein degraders. We discuss the challenges of isoform selectivity, species-specific differences, and the therapeutic potential of HDAC-based strategies to attenuate aberrant NLRP3 activity while minimizing off-target effects. Understanding this epigenetic-inflammasome crosstalk may provide a framework for translating epigenetic modulation into innovative treatments for inflammasome-driven diseases.

🚀 New Perspective in J Med Chem out now! #HDACs meet #NLRP3 #inflammasome 🔬 Many thanks for the great collaboration! #DrugDiscovery
pubs.acs.org/doi/10.1021/...

#FusobacteriumNucleatum–induced #neutrophil EVs carrying NETs are internalized by intestinal epithelial cells, activating the AIM2 #inflammasome, exacerbating #UlcerativeColitis and highlighting the nEVs–NETs/AIM2 axis as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Inflammasome Dynamics in Psoriasis: AIM2, NLRP3, and NLRP1 at the Interface of Inflammation and Immunity - Premier Science AIM2, Inflammasome, NLRP1, NLRP3, Psoriasis, Autoinflammatory disorder.

doi.org/10.70389/PJS...

#psoriasis #inflammasome #AIM2 #NLRP3 #NLRP1 #inflammation #immunity

Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases - Molecular Neurodegeneration Molecular Neurodegeneration - Organelle stress and NLRP3 inflammasome activation have been established as pivotal contributors to inflammatory responses and play a significant role in the...

#Organelle stress in NLRP3 #inflammasome: a central mediator of #neurodegenerative diseases

Huachao Jia, Lianghua Ma...Wanwei Jiang, Minjie Wei, Xin Zhong

link.springer.com/article/10.1...

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action, from Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social and colleagues 👉 rupress.org/jem/article/...

📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...

#Inflammasome

Pauline Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq, which classifies MEFV variants of uncertain significance to refine molecular diagnostics and improve our knowledge on the pyrin #inflammasome rupress.org/jem/article/...

#HumanDiseaseGenetics #Autoimmunity #Autoinflammation

Here is the latest paper of the lab @ciri-lyon.bsky.social on the pyrin #inflammasome, the MEFV gene variants and the associated autoinflammatory diseases, Familial Mediteranean fever (FMF) and PAAND.

#Research

ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity doi.org/10.1186/s435...

#ML345 #NLRP3 #inflammasome #inhibitor #NEK7 #InflammatoryDisease #Miscarriage

Neutrophil extracellular traps and peptidylarginine deiminase 4–mediated inflammasome activation link diabetes to cardiorenal injury and heart failure AbstractBackground and Aims. Diabetes is associated with increased risk of cardiovascular and renal disease. This study investigated the role of peptidylar

🥳 I am thrilled to share my first paper since starting my research fellowship at @harvardmed.bsky.social and @bostonchildrens.bsky.social
👏 Congrats Nicolas Schommer, Lukas Heger and Denisa Wagner.Thanks for adding me
❤️‍🩹 #Diabetes #NETs #PAD4 #Inflammasome #HF

academic.oup.com/eurheartj/ad...

🧬 #CRISPR, #Glial reprogramming & #Inflammasome blockers 💥—new tools to rewire #Aging from within #Epigenetics, #NeuroRepair, #Longevity @mdpiopenaccess.bsky.social
💡 Explore 👉
doi.org/10.20944/pre...

Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation - Cell Death & Disease Cell Death & Disease - Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation

Sharing our latest work on #AMD and how dampening #Nlrp3 #inflammasome signaling protects against #BLamD retinal pathology in multiple mouse models.

www.nature.com/articles/s41...

Signalling Pathways of Innate Immunity In this cross-journal Collection, we invite research into the complex signalling pathways of innate immunity, emphasising the activation and regulation of ...

🔔Our cross-journal collection #Signalling Pathways of #Innate #Immunity handled by our editorial board member Si Ming Man has been extended until 28 February 2026!
We are looking forward to your submissions! #cGAS-STING #Toll-like & #NOD-like receptors #inflammasome
www.nature.com/collections/...

The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage | The EMBO Journal imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and viruses in the gastrointestinal tract by a poorly-understood mechanism. This study shows that NLRP6 forms...

Our latest work from @brozlab.bsky.social and led by @alexandraboegli.bsky.social is out now in @embojournal.org. Check out our findings on how the intestinal #inflammasome NLRP6 senses lysosomal damage to trigger pyroptotic cell death.

The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....

ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity - Molecular Biomedicine Excessive activation of the NOD-like receptor pyrin domain–containing protein 3 (NLRP3) inflammasome plays a key role in the pathogenesis of various inflammatory diseases. Despite the development of s...

#Research
ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity doi.org/10.1186/s435...

#ML345 #NLRP3 #inflammasome #inhibitor #NEK7 #InflammatoryDisease #Miscarriage

ScienceDirect.com | Science, health and medical journals, full text articles and books.

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

4️⃣ Innovation
🧬 #CRISPR, #Glial reprogramming & #Inflammasome blockers 💥—new tools to rewire #Aging from within #Epigenetics, #NeuroRepair, #Longevity @mdpiopenaccess.bsky.social
💡 Explore 👉
doi.org/10.20944/pre... #FutureOfNeuroscience #RetweetScience