Recombinant viruses encode inflammasome reporter caspase-1 CARD-EGFP and inhibitory AIM2 nanobodies, which block inflammasome assembly in macrophages, but not monocytes.

... and engineered reporter poxviruses to impair AIM2 inflammasomes in human primary cells with inhbitory nanobodies, revealing that primary macrophages and keratinocytes assemble #AIM2 inflammasomes, while monocytes assemble #NLRP3 inflammasomes.

Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...

Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to ‬dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...

Inflammasome Dynamics in Psoriasis: AIM2, NLRP3, and NLRP1 at the Interface of Inflammation and Immunity - Premier Science AIM2, Inflammasome, NLRP1, NLRP3, Psoriasis, Autoinflammatory disorder.

doi.org/10.70389/PJS...

#psoriasis #inflammasome #AIM2 #NLRP3 #NLRP1 #inflammation #immunity

Amit Shah thanks PM Modi as Cabinet approves Rs 2,750 crore for AIM 2.0 - Yes Punjab News Union Cabinet approves Rs 2,750 crore for Atal Innovation Mission 2.0 to boost India's innovation and entrepreneurship ecosystem. Amit Shah thanks PM Modi for visionary initiative.

Amit Shah thanks PM Modi as Cabinet approves Rs 2,750 crore for AIM 2.0
yespunjab.com?p=65482

#AtalInnovationMission #AIM2 #AmitShah #PMModi #NITIayog #YouthEmpowerment #Entrepreneurship #ViksitBharat #GlobalInnovationIndex #StartupsInIndia #AIMInitiative