IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella - EMBO Reports IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...

IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...

Health officials warn of rise in tularemia cases in Minnesota The illness is caused by the bacteria Francisella tularensis. It's commonly found in small rodents, rabbits, squirrels and beavers. People typically develop the illness from tick and fly bites,…

Warning of rise in #tularemia incidences in #Minnesota ...

| #rabbitfever | #bacteria | #Francisella | #pathogen | #publichealth | Via @cbsnews.com

Surveillance of zoonotic pathogens in small mammals across a gradient of forest anthropization in Eastern France The emergence of infectious diseases associated with land-use changes is well-documented. However, zoonotic risks originating from European forests, whether from rural development or urban greening, r...

Our latest preprint:
🦠🐭 Small mammals in French forests host a wide array of potentially #zoonotic #pathogens, including #hantaviruses, #Leptospira, #Francisella...
But how does forest #anthropization shape their richness, prevalence, and community structure?
👉 www.biorxiv.org/content/10.1...