Physiological balance in infection. In a #vaccinia model, ISG15 or OMA1 deficiency leads to lower viral titers by day 7 (more ISGs), but also shows impaired #apoptotic cell clearance (more tissue damage), illustrating the trade off the axis manages during #resolution. #immunosky
Function: #efferocytosis gets a boost. IFN-I increases #apoptotic cell uptake by macrophages. This requires #ISG15; #OMA1 mitochondrial protease is dispensable for this step. ISG15 deficiency shows impaired clearance of #apoptotic cells in vivo in thymic or peritoneal challenges. #Immunosky
Bone marrow MSCs‑derived #apoptotic vesicles drive M0→M2 #macrophage polarization through miR‑21a‑5p/CCL‑1 targeting, regulating #inflammation and #angiogenesis to synergistically promote #WoundHealing, offering a promising therapeutic strategy.
#OpenAccess: doi.org/10.1016/j.ge...
This study identifies #SaltInducibleKinases, especially SIK3, as inhibitors of #macrophage efferocytosis in #RheumatoidArthritis, showing that SIK inhibition enhances #apoptotic cell clearance, #M2polarization, and Treg differentiation.
#OpenAccess #STTT: doi.org/10.1038/s413...
This latest review explores the role of miR-23b in #Cancer, showing how it drives #Tumorigenesis via #Wnt/β-catenin signaling and #Apoptotic proteins such as #BCL2, positioning miR-23b as a potential target in cancer prognosis and therapy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis
Single-cell RNA sequencing (#RNAseq) and bulk- RNA-seq analysis reveal that endothelial cells can engulf #apoptotic cell debris in #AtheroscleroticPlaque through SR-B1, which is associated with the reorganization of cellular adherent junctions and the #cytoskeleton.
#OpenAccess: buff.ly/WHuKGgF
Filopodial projections crowed #pyroptotic & #necroptotic corpses, but not #apoptotic corpses - even when apoptosis was triggered by #inflammasome signalling in GSDMD-null cells. So filopodia = a flag that a cell lysed 'under suspicious circumstances' ⛳️ (7/13)
Meme: @arnaudjlegrand.bsky.social
