Physiological balance in infection. In a #vaccinia model, ISG15 or OMA1 deficiency leads to lower viral titers by day 7 (more ISGs), but also shows impaired #apoptotic cell clearance (more tissue damage), illustrating the trade off the axis manages during #resolution. #immunosky
Protective #efficacy of a genetically modified attenuated #vaccinia virus #Tiantan strain against #monkeypox virus challenge in a small animal #model, etidiohnew.blogspot.com/2026/01/prot...
The heterologous prime-boost regimen combining DNA with replication-competent Tiantan #vaccinia vectors demonstrate favorable safety & tolerability while eliciting robust humoral and cellular immunity against #HIV antigens.
#STTT #OpenAccess: doi.org/10.1038/s413...
2013: We discovered that the human protein, SAMHD1, protects against DNA viruses (like herpes and pox) by lowering the concentration of dNTPs (resources for viral replication) in infected cells.#virology #virus #immunology #microbiology #vaccinia
journals.plos.org/plospathogens/…
In 2013, I developed a qPCR assay to detect and quantify poxviruses. The assay worked as well as traditional methods, but was much faster and more amenable to high-throughput.#virology #vaccinia #qPCR #virus #poxvirus #microbiology
pubmed.ncbi.nlm.nih.gov/24211297/
First time in 3D and atomic resolution: Researchers of @CramerLab and @Uni_WUE succeeded in "filming" how #Vaccinia viruses propagate. https://www.mpibpc.mpg.de/17144763/pr_1930?c=80187 @CellPressNews
First time in 3D and atomic resolution: Researchers of @CramerLab and @Uni_WUE succeeded in "filming" how #Vaccinia viruses propagate. https://www.mpibpc.mpg.de/17144763/pr_1930?c=80187 @CellPressNews
First time in 3D and atomic resolution: Researchers of @CramerLab and @Uni_WUE succeeded in "filming" how #Vaccinia viruses propagate. https://www.mpibpc.mpg.de/17144763/pr_1930?c=80187 @CellPressNews
First time in 3D and atomic resolution: Researchers of @CramerLab and @Uni_WUE succeeded in "filming" how #Vaccinia viruses propagate. https://www.mpibpc.mpg.de/17144763/pr_1930?c=80187 @CellPressNews
First time in 3D and atomic resolution: Researchers of @CramerLab and @Uni_WUE succeeded in "filming" how #Vaccinia viruses propagate. https://www.mpibpc.mpg.de/17144763/pr_1930?c=80187 @CellPressNews
First time in 3D and atomic resolution: Researchers of @CramerLab and @Uni_WUE succeeded in "filming" how #Vaccinia viruses propagate. https://www.mpibpc.mpg.de/17144763/pr_1930?c=80187 @CellPressNews
