An overview of #Purinergic receptor dysregulation in #Osteoarthritis, detailing its roles in #SynovialInflammation, cartilage homeostasis, subchondral #BoneRemodeling, and pain transmission and strategies targeting purinergic receptors.

#OpenAccess: doi.org/10.1016/j.ge...

This #STTT study identified SIK3 as an inhibitor of macrophage #Efferocytosis, demonstrating that SIK inhibition promotes M2 polarization & Treg differentiation to alleviate #SynovialInflammation & bone destruction in RA.

#OpenAccess: doi.org/10.1038/s413...