An overview of #Purinergic receptor dysregulation in #Osteoarthritis, detailing its roles in #SynovialInflammation, cartilage homeostasis, subchondral #BoneRemodeling, and pain transmission and strategies targeting purinergic receptors.

#OpenAccess: doi.org/10.1016/j.ge...

Lin, F.I., Rao, J.E., Mittra, E.S. et al. Prospective comparison of combined 18F-FDG and 18F-NaF PET/CT vs. 18F-FDG PET/CT imaging for detection of malignancy. Eur J Nucl Med Mol Imaging 39, 262–270 (2012).

[18F]FDG+[18F]NaF PET-CT vs [18F]FDG PET-CT imaging for detection of malignancy #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #CancerResearch #BoneRemodeling doi: 10.1007/s00259-011-1971-1

Boivin G, Farlay D, Khebbab MT, Jaurand X, Delmas PD, Meunier PJ. In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. Osteoporos Int. 2010 Apr;21(4):667-77. doi: 10.1007/s00198-009-1005-z. Epub 2009 Jul 14. PMID: 19597910.

Strontium Ranelate Keeps Bones Strong: How It Supports Healthy Bone Formation in Osteoporotic Women! #BoneHealth #HealthyBones #Osteoarthritis #BoneResearch #ImagingInnovation #StrongBones #BoneWellness #BoneStrength #BoneRemodeling #EarlyDetection doi: 10.1007/s00198-009-1005-z

Even-Sapir E, Metser U, Mishani E, Lievshitz G, Lerman H, Leibovitch I. The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT. J Nucl Med. 2006 Feb;47(2):287-97. PMID: 16455635.

[18F]NaF PET for Detecting Bone Metastases in Prostate Cancer Patients #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #BoneImaging #BoneRemodeling #EarlyDetection #prostatecancer #cancer jnm.snmjournals.org/content/47/2...

Puri T, Frost ML, Moore AEB, Cook GJR, Blake GM. Input function and modeling for determining bone metabolic flux using [18 F] sodium fluoride PET imaging: A step-by-step guide. Med Phys. 2023 Apr;50(4):2071-2088. doi: 10.1002/mp.16125. Epub 2022 Dec 17. PMID: 36433629.

[18F] NaF PET Ki vs SUV? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging #BoneRemodeling #EarlyDetection #ArthritisAwareness doi: 10.1002/mp.16125

Ota N, Kato K, Iwano S, Ito S, Abe S, Fujita N, et al. Comparison of 18F-fluoride PET/CT, 18F-FDG PET/CT and bone scintigraphy (planar and SPECT) in detection of bone metastases of differentiated thyroid cancer: a pilot study. Br J Radiol 2014;87:20130444.

[18F]NaF PET in differentiated thyroid carcinoma
#18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #BoneImaging #BoneRemodeling doi: 10.1259/bjr.20130444

Special Issue Information (Submission Deadline: 20 May 2025) #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #BoneImaging #BoneRemodeling #EarlyDetection www.mdpi.com/journal/jcm/...

Kuo J, Foster C, Shelton D. Particle disease on fluoride-18 (NaF) PET/CT imaging. J Radiol Case Rep. 2011;5(5):24-30. doi: 10.3941/jrcr.v5i5.697. Epub 2011 May 1. PMID: 22470793; PMCID: PMC3303443.

Particle Disease on [18F]NaF PET-CT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #Osteoarthritis #BoneResearch #ImagingInnovation #BoneWellness #BoneImaging #BoneRemodeling doi: 10.3941/jrcr.v5i5.697

Usmani S, Rasheed R, Al Kandari F. Textitis as Seen on 18F-NaF Imaging Using an Ultra-High-Resolution Positron Emission Mammography Scanner. J Nucl Med Technol. 2020 Jun;48(2):181-183. doi: 10.2967/jnmt.119.235986. Epub 2020 Feb 28. PMID: 32111663.

Smartphone Overuse Strain Caught on [18F]NaF PET-CT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #BoneHealth #JointCare #HealthyBones #BoneResearch #ImagingInnovation #BoneWellness #BoneImaging #BoneRemodeling #EarlyDetection doi: 10.2967/jnmt.119.235986

Revision of the 1994 World Health Organization T-score definition of osteoporosis for use in older East Asian women and men to reconcile it with their lifetime risk of fragility fracture - Skeletal Ra... The 1994 WHO criterion of a T-score ≤ -2.5 for densitometric osteoporosis was chosen because it results in a prevalence commensurate with the observed lifetime risk of fragility fractures in Caucasian...

New T-score Guidelines for Osteoporosis in East Asians #BoneHealth #JointCare #HealthyBones #Osteoarthritis #BoneResearch #JointHealth #ImagingInnovation
#StrongBones #BoneWellness #CartilageCare #BoneImaging #BoneStrength #BoneRemodeling #EarlyDetection #ArthritisAwareness doi.org/10.1007/s002...

Papadakis GZ, Jha S, Bhattacharyya T, Millo C, Tu TW, Bagci U, Marias K, Karantanas AH, Patronas NJ. 18F-NaF PET/CT in Extensive Melorheostosis of the Axial and Appendicular Skeleton With Soft-Tissue Involvement. Clin Nucl Med. 2017 Jul;42(7):537-539. doi: 10.1097/RLU.0000000000001647. PMID: 28319505; PMCID: PMC5453819.

[18F]NaF PET for Melorheostosis #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging #BoneRemodeling #EarlyDetection
doi: 10.1097/RLU.0000000000001647

Papadakis GZ, Millo C, Bagci U, Blau J, Collins MT. 18F-NaF and 18F-FDG PET/CT in Gorham-Stout Disease. Clin Nucl Med. 2016 Nov;41(11):884-885. Multiple foci of intensely increased 18F-NaF activity located in the right posterior ribs (Fig. 2A: 18F-NaF MIP image red arrows; Fig. 2B: axial fused 18F-NaF-PET/CT image white arrow, SUVmax: 84,5) were associated with areas of incipient bone resorption (Fig. 2C: axial chest CT-image bone window, white arrow) supporting the application of 18F-NaF as the optimal bone-seeking PET-radiopharmaceutical to assess GSD activity.

[18F]NaF PET-CT in Gorham-Stout Disease #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging #BoneRemodeling #EarlyDetection doi:10.1097/RLU.0000000000001369

PET/MRI of right knee of 36 year male having KL grade 0 showing high tracer uptake in medial central femur region (B) without any morphological changes in corresponding sagittal T2 SPIR image (A) also spatially correlated on fused PET/MRI image (C). Grade 1 osteophyte in lateral posterior tibial region in sagittal T1 TSE image (D) showing increased tracer uptake in PET (E) better appreciated on fused PET/MRI image (F). The T2 ∗ relaxometry cartigram overlayed on sagittal T2 SPIR image (G) showed mild changes in the cartilage of medial aspect of tibia (Green arrow for osteophytes and yellow arrow for region having intense tracer uptake without morphological changes). Physiological uptake was noted at tendon insertion sites on patella & tibial tuberosity. Jena A, Goyal N, Vaishya R. 18F-NaF simultaneous PET/MRI in osteoarthritis: Initial observations with case illustration. J Clin Orthop Trauma. 2021 Aug 26;22:101569. doi: 10.1016/j.jcot.2021.101569. PMID: 34513587; PMCID: PMC8411223. Keywords: Osteoarthritis (OA), PET/MRI, 18F–NaF, Standard uptake value (SUV)

[18F]NaF PET in osteoarthritis #18FNaF #BoneHealth #JointCare #HealthyBones #Osteoarthritis #BoneResearch #JointHealth #ImagingInnovation #StrongBones #BoneWellness #CartilageCare #BoneImaging #BoneRemodeling #EarlyDetection #ArthritisAwareness doi: 10.1016/j.jcot.2021.101569