In-vivo measurement of the extracellular ATP concentration by bio-luminescence: The pmeLUC probe Extracellular ATP (eATP) serves as a crucial signaling molecule in diverse physiological and pathological processes, including neurotransmission, infl…

The pmeLUC probe - a new, handy way to measure extracellular ATP in vivo published by our consortium members #P2X7 #purinergicsignalling 👨‍🔬 www.sciencedirect.com/science/chap...

¿Por qué una proteína acelera el Parkinson y cómo frenarla? Un PET clave señala al receptor P2X7 como motor inflamatorio del párkinson y abre vías para frenar síntomas y progresión objetiva con datos. El avance del párkinson no se explica solo por la pérdida d...

¿Por qué una proteína acelera el Parkinson y cómo frenarla?
#Parkinson #Neuroinflamación #P2X7 #Microglía #PET #AlfaSinucleína #CuerposDeLewy #Biomarcadores #Investigación #Salud #UniversidadDeMessina #30denoviembre #felizdomingo
donporque.com/por-que-una-...

Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports imageimageStressed brown adipocytes release extracellular ATP, which acts as a paracrine signal via P2X4 and P2X7 receptors on macrophages, initiating BAT inflammatory remodeling and degeneration. Blocking this purinergic signaling axis prevents ...

Fantastic study by Michelle Jäckstein and Jörg Heeren of #SFB1328. Only the inhibition of both - #P2X7 and #P2X4 - protects from BAT inflammation!!! It was a pleasure to collaborate! Hope this inspires others to check P2X4/P2X7 double inhibition in their models! www.embopress.org/doi/full/10....

Thomas Grutter (Université de Strasbourg)
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule

Marylou Pichonnière (UMR1327 ISCHEMIA, Tours)
"Extracellular nanovesicles as potential biomarkers of kidney-graft function recovery"
📊 EVs as a non-invasive window into renal recovery.
#FPC2025 #Transplantation #Biomarkers #P2X4 #P2X7 #KidneyTransplantation

🎙️ Podcast shorturl.at/vNono
📹 YouTube shorturl.at/aeV1F
✍️ Show notes shorturl.at/FxPBw

#epilepsy #P2X7 #TBI #neuroscience #EpilepsyResearch #BrainInjury #Neuroprotection

Within Pur-Ther, we are looking into purinergic checkpoints like P2X7, CD73, and CD39, and their role in the tumor microenvironment.
Stay tuned for insights and discoveries shaping the future of immunotherapies! 🌟 🧑‍🔬 👨‍🔬 ⚗️

#PurinergicSignaling #P2X7 #ATP #Immunotherapy #TRANSCAN

Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice Previous studies have suggested a significant role of pannexin 1 (Panx1)/P2X7 receptor complex in cardioprotective mechanism of ischemic preconditioni…

Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice #MECFS #LongCovid #PANX1 #P2X7 #SARSCoV2

www.sciencedirect.com/science/arti...