Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports imageimageStressed brown adipocytes release extracellular ATP, which acts as a paracrine signal via P2X4 and P2X7 receptors on macrophages, initiating BAT inflammatory remodeling and degeneration. Blocking this purinergic signaling axis prevents ...

Fantastic study by Michelle Jäckstein and Jörg Heeren of #SFB1328. Only the inhibition of both - #P2X7 and #P2X4 - protects from BAT inflammation!!! It was a pleasure to collaborate! Hope this inspires others to check P2X4/P2X7 double inhibition in their models! www.embopress.org/doi/full/10....

It is always a pleasure to get young students enthusiastic about science! A few days ago we had a whole class in our department, showcasing #Nanobody research. What can I say - it was fun! Hope to see some of you around on campus some time! #sfb1328

Flow Cytometric Analysis of Mouse Brain CD8+ T Cell Activation Cytotoxic CD8+ T cell lymphocytes are pivotal for fighting infections with intracellular pathogens, e.g., viruses. Moreover, recent studies have elucidated the role of CD8+ T cells in various neuroinf...

I am happy to report that our chapter on "Flow Cytometric Analysis of Mouse Brain CD8+ T Cell Activation" is out now! It is part of a book on "T cell activation" curated and edited by Björn-Philipp Diercks of #sfb1328
link.springer.com/protocol/10....

Call for Papers – Purinergic Signaling: Medicinal Chemistry, Biology, Pharmacology, and Translation into Diagnostic and Therapeutic Drugs OR SEARCH CITATIONS

Exciting special issue coming up in 2025: #purinergic signaling is a fascinating cellular communication hub in many different organ and tissue systems…including the immune system. The special issue is curated and edited by colleagues from #SFB1328.

pubs.acs.org/doi/10.1021/...