Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports imageimageStressed brown adipocytes release extracellular ATP, which acts as a paracrine signal via P2X4 and P2X7 receptors on macrophages, initiating BAT inflammatory remodeling and degeneration. Blocking this purinergic signaling axis prevents ...

Fantastic study by Michelle Jäckstein and Jörg Heeren of #SFB1328. Only the inhibition of both - #P2X7 and #P2X4 - protects from BAT inflammation!!! It was a pleasure to collaborate! Hope this inspires others to check P2X4/P2X7 double inhibition in their models! www.embopress.org/doi/full/10....

Marylou Pichonnière (UMR1327 ISCHEMIA, Tours)
"Extracellular nanovesicles as potential biomarkers of kidney-graft function recovery"
📊 EVs as a non-invasive window into renal recovery.
#FPC2025 #Transplantation #Biomarkers #P2X4 #P2X7 #KidneyTransplantation

The French Purine Club is happy to introduce you to the speakers for our second Webinar
To attend the webinar, save the date and please follow the link: u-bordeaux-fr.zoom.us/j/81139788609

Save the date: April 10th, 4 pm CEST

Please RT
#Purine #Webinar #metabolism #P2Y #P2X4 #microglia #adenosine

Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders

Happy to share our latest paper on #P2X4 and published with@SpringerNature in Neuroscience Bulletin- Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders- Read and share here:

rdcu.be/b6P1V