🚀From Bench to Paper | New study in #Science (Tuan-Anh Nguyen, et al): #NUDT5 regulates #purine de novo synthesis by inhibiting #PPAT.
🌟#Nucleotide Compound Library (HY-L044) and #Hoechst 33342 trihydrochloride (HY-15559A) from MedChemExpress was used in this research.
We then turned to #NUDT5, not previously tied to pyrimidine metabolism.
We found that NUDT5 binds and regulates #PPAT, the rate-limiting enzyme in #purine synthesis, and this regulation is independent of its catalytic activity!
6/17
The next European #Purine Meeting will be hosted by the French Purine Club in Bordeaux in 2026 with the important support of the EU COST Presto coordinated by Prof. Elena Adinolfi.
ADSL Deficiency is a metabolic disorder AND a mitochondrial disorder. Damn dude…
#adsldeficiency
#mitochondria
#raredisease
#purine
The latest pre-print from the lab is out! 🥳
In this work led by our PhD student Abigail, the @jourdainlab.bsky.social adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.
Adénine de la chatte
L'adénine est une purine, constituant essentiel des acides nucléiques, qui joue un rôle crucial dans le stockage et la transmission de l'information génétique. #Adenine #Purine #Acides #Genetique #Information
When thinks start making sense "Global niche partitioning of #purine and #pyrimidine cross-feeding among #ocean #microbes"
doi.org/10.1126/scia...
#cyanobacteria #prochlorococcus #bacteria #marine
Tags les plus utilises dans les messages en francais au cours des 60 dernieres minutes:
1) #orion
2) #genchat
3) #france
4) #sutom
5) #1100
6) #musicchallenge
7) #purine
8) #frenchpurineclub
9) #webinar
10) #neuroscience
#trendingtags #tendances
Save the date for the 3rd Webinar of the French
#Purine Club!
📅 February 10, 2025 – 9:30 am (Paris)
Join top experts discussing purinergic signaling:
👉 cnrs.zoom.us/j/9272487474...
📲 Zoom ID: 927 2487 4749
🔑 Password: JcdU7G
#FrenchPurineClub #Webinar #Neuroscience
Save the date for the 3rd Webinar of the French #Purine Club!
📅 February 10, 2025 – 9:30 am (Paris)
Join top experts discussing purinergic signaling:
👉 cnrs.zoom.us/j/9272487474...
📲 Zoom ID: 927 2487 4749
🔑 Password: JcdU7G
#FrenchPurineClub #Webinar #Neuroscience
Dit is de #Murchison-meteoriet. 1969 ingeslagen in Australië. Bijzonder omdat deze 7 miljard jaren oude ‘steen’ 14000 verschillende organische verbindingen bevat waaronder #Purine und #Pyrimidine, basis bouwstenen van #DNA en RNA. Zijn we dus wel degelijk uit #sterrenstof ontstaan.
The French Purine Club is happy to introduce you to the speakers for our second Webinar
To attend the webinar, save the date and please follow the link: u-bordeaux-fr.zoom.us/j/81139788609
Save the date: April 10th, 4 pm CEST
Please RT
#Purine #Webinar #metabolism #P2Y #P2X4 #microglia #adenosine
