Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors - Nature Communications Microbial evolution often involves transient phenotypes and sequential development of multiple mutations of unclear relevance. Here, the authors show that the evolution of non-growing E. coli cells…

🥄 What if DNA molecules controlled bacteria's food choices? A study from @dtu.dk reveals how #pyrimidines impact carbon metabolism in E. coli. Researchers used modular #pSEVA27 plasmids to explore Crp protein variants. 🔗 Read more:

#MRSA #brinsmadelab #pyrimidines #bacterialpathogenesis #virulence #regulation #pyrimidinesareimportanttoo #twocomponentsystems #membranebiosynthesis #georgetownbiology

The latest pre-print from the lab is out! 🥳

In this work led by our PhD student Abigail, the @jourdainlab.bsky.social adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.