Also thanks to @ki.se, @scilifelab.se, @novonordisk.bsky.social, Cancerfonden, and Barncancerfonden for continued support.
#NUDT5 #metabolism #thiopurines #chemotherapy #cancer #biomarker #PROTACs #TPD
4/4
🚀From Bench to Paper | New study in #Science (Tuan-Anh Nguyen, et al): #NUDT5 regulates #purine de novo synthesis by inhibiting #PPAT.
🌟#Nucleotide Compound Library (HY-L044) and #Hoechst 33342 trihydrochloride (HY-15559A) from MedChemExpress was used in this research.
Publiés dans @natmetabolism.nature.com, ces travaux positionnent #NUDT5 comme un biomarqueur prometteur pour #prédire la résistance thérapeutique dans le cancer, les maladies auto-immunes et les infections virales, ce qui aidera à guider les praticien·nes dans leur choix de thérapies.
After our bioRxiv upload in March, THREE related #NUDT5 preprints appeared on-line! 🤯
We kept in touch with the authors and tried our best to coordinate publication. Here are some links, also to older relevant papers:
10/17
Our findings link fundamental nucleotide metabolism to clinical outcomes, highlighting #NUDT5 as a biomarker for predicting therapy efficacy in cancer, autoimmune, and viral diseases.
Huge thanks to all co-authors and funders! @snsf_ch
And now, some exciting related work 👇
9/17
We then turned to #NUDT5, not previously tied to pyrimidine metabolism.
We found that NUDT5 binds and regulates #PPAT, the rate-limiting enzyme in #purine synthesis, and this regulation is independent of its catalytic activity!
6/17
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
A new @science.org study by CeMM PI Stefan Kubicek's group & @ox.ac.uk collaborators reveals that the #NUDT5 enzyme regulates purine synthesis, acting as a scaffold to stop DNA building block production when levels are high.
➡️Read more: https://bit.ly/4hLMpJ5
📄Publication: https://bit.ly/4qJogXN
Congrats to first author, Seher Alam, and thanks to all students and collaborators!
We're grateful for support from @scilifelab.se, @novonordisk.bsky.social, and Cancer Research KI, as well as fellowships from Barncancerfonden and Cancerfonden.
Fin
#TPD #PROTAC #CeTEAM #NUDT5
The latest pre-print from the lab is out! 🥳
In this work led by our PhD student Abigail, the @jourdainlab.bsky.social adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.
