🚀From Bench to Paper | New study in #Science (Tuan-Anh Nguyen, et al): #NUDT5 regulates #purine de novo synthesis by inhibiting #PPAT.

🌟#Nucleotide Compound Library (HY-L044) and #Hoechst 33342 trihydrochloride (HY-15559A) from MedChemExpress was used in this research.

We then turned to #NUDT5, not previously tied to pyrimidine metabolism.

We found that NUDT5 binds and regulates #PPAT, the rate-limiting enzyme in #purine synthesis, and this regulation is independent of its catalytic activity!

6/17

🌐 #Online #Events 🗓️ #October2025

🗺️👠👥 #NSWP
🗺️🏥👥 #IPPF (@ippf.bsky.social — thanks so very much~! 💗)
🌏👠👥 #APNSW
🇹🇭🏥👥 #PPAT
🇹🇭👠👥 #SWING
🇮🇩🏥👥 #PKBI
🇮🇩👠👥 #OPSI
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État du parc immobilier français : quels enjeux techniques pour les professionnels de l'immobilier ? buff.ly/JpTt3aG #immobilier #PPAT #équipements #gestionnaires

IPPAT Kabupaten Tangerang, Bupati Tangerang: PPAT Garda Terdepan Atasi Konflik Tanah & Dorong Ekonomi Daerah - seketika.com Bupati Tangerang tegaskan pentingnya peran PPAT dalam pembangunan & tata kelola pertanahan. IPPAT siap dukung pelayanan pertanahan yang profesional!

Konflik tanah makin marak?

Bupati Tangerang tegaskan PPAT harus jadi garda terdepan jaga hak rakyat & bantu perekonomian!

Setuju PPAT harus lebih aktif?" 👇
#Tangerang #Pertanahan #IPPAT #PPAT #Pembangunan #Banten #update #news #seketika
www.seketika.com/ippat-kabupa...

🧩 We made two key observations for the mechanism:
(1) NUDT5 binds to and oligomerizes with #PPAT, the first and rate-limiting enzyme in purine synthesis
(2) PPAT depletion rescues pyrimidine synthesis in NUDT5-KO cells #epistasis

But why pyrimidines?!?

5/9