TNFα-driven FSP1 upregulation accelerates intervertebral disc degeneration through Caspase-3–dependent apoptosis.
#IntervertebralDiscDegeneration #TNFalpha #FSP1 #Caspase3 #Apoptosis #DiscBiology
doi.org/10.1016/j.ge...
FSP1 drives #IntervertebralDiscDegeneration by promoting TNFa-mediated #Apoptosis by activating NF-κB signaling & caspase 3 in nucleus pulposus cells, offering a novel #TherapeuticTarget for chronic lower back pain.
#OpenAccess: doi.org/10.1016/j.ge...
This study identifies #FSP1 as a key promoter of #IntervertebralDiscDegeneration (IDD) through #TNFα-reliant #NFκB signaling and #Caspase3-dependent #Apoptosis, positioning FSP1 as a novel #therapeutic target for IDD. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
This recent review explores #CellularSenescence in #IntervertebralDiscDegeneration, summarizing detection methods, #RegulatoryMechanisms, & therapies to inhibit #Senescence, & also addresses the challenges in #Clinical applications. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Published in Bone Research, a study showed that SIRT6 loss disrupted cellular balance, triggering inflammation, chromatin changes, DNA damage, and signs of premature cellular aging.
#intervertebraldiscdegeneration #Sirt6
Details: doi.org/10.1038/s41413-025-00422-3
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis
FSP1 promotes #IntervertebralDiscDegeneration (IDD) through the activation of TNFα-dependent NF-κB signaling and caspase 3-dependent #apoptosis, thereby acting as a novel therapeutic target for the treatment of IDD. #Ferroptosis #medsky
#OpenAccess: buff.ly/2zDl85i
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis
This new study uncovers the functions of FSP1 during #IntervertebralDiscDegeneration (IDD) through TNFα-reliant caspase 3-dependent apoptosis and provides a novel molecular target for the treatment of IDD.
#OpenAccess: www.sciencedirect.co...
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis
This new study uncovers the functions of FSP1 during #IntervertebralDiscDegeneration (IDD) through TNFα-reliant caspase 3-dependent apoptosis and provides a novel molecular target for the treatment of IDD.
#OpenAccess: https://buff.ly/4h8ZL0S
