🔥Hot Off the Press | New study in #Nature: Blocking #FSP1 unleashes #ferroptosis in #lung #cancer: massive tumor suppression, correlates with worse survival in patients, and points to a new therapeutic target. 🧬
Read more: www.nature.com/articles/s41...
#LungCancer #TumorSuppression

📰New & Featured | #FSP1: Targeting Lymph Node #Melanoma
A #Nature study shows melanoma shifts to depend on FSP1 in lymph nodes. FSP1 inhibitors reduce lymph node tumor growth, blocking melanoma spread in a microenvironment-specific manner. 🔗https://www.medchemexpress.com/

This study identifies #FSP1 as a key promoter of #IntervertebralDiscDegeneration (IDD) through #TNFα-reliant #NFκB signaling and #Caspase3-dependent #Apoptosis, positioning FSP1 as a novel #therapeutic target for IDD. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

🚨Preprint alert 🚨

We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.

www.biorxiv.org/content/10.1....

pls check @olzmannlab.bsky.social

www.biorxiv.org/content/10.1...

#ferroptosis #FSP1 #antioxidants

Published on February 28, 2024, in Genes & Diseases, researchers have identified Ferroptosis Suppressor Protein 1 (FSP1) as a central factor in intervertebral disc degeneration.
#Caspase 3 #FSP1
Details: doi.org/10.1016/j.gendis.2024.101251