Brepocitinib VALOR Trial Shows Significant Benefit Brepocitinib 30 mg daily produced a 60% responder rate vs 30% placebo at week 16; NEJM published VALOR results on Mar 28, 2026, reshaping dermatomyositis treatment debate.

Brepocitinib VALOR Trial Shows Significant Benefit: Brepocitinib 30 mg daily produced a 60% responder rate vs 30% placebo at week 16; NEJM published VALOR results on Mar 28, 2026, reshaping dermatomyositis… 👈 Read full analysis #Brepocitinib #VALORTrial #Dermatomyositis #ClinicalTrials #NEJM

As a medical school professor, I can tell you: the New England Journal of Medicine just published something historic.

For the f... medicalxpress.com/news/2026-03-scientists-...

#MetabolicHealth #ChronicDisease #PublicHealth #NEJM #HealthLongevitySecrets

Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction | NEJM The preferred timing of treatment of nonculprit lesions in patients with ST-segment elevation myocardial infarction (STEMI) remains uncertain. A comparison of immediate percutaneous coronary interv...

Great to see this very important and topical RCT which was conducted by @bhcintervention.bsky.social at @bartsintervention.bsky.social published in #NEJM www.nejm.org/doi/full/10....
Immediate or Deferred Nonculprit-Lesion PCI in MI (iMODERN) Study

@krishnaraj82.bsky.social

https://www.nejm.org/doi/10.1056/NEJMoa1407647

#cowpox #nejm t.co/5h7NeaKtXX

Phase 1 Study of Rezatapopt, a p53 Reactivator, in TP53 Y220C–Mutated Tumors | NEJM Rezatapopt is an investigational, first-in-class, oral, selective p53 reactivator that specifically binds to Y220C-mutated p53, which stabilizes p53 in its wild-type conformation and restores its f...

This latest phase I study in #NEJM of a first-in-class, ORAL! selective #p53 reactivator looks promising

Biomarkers that we were forced to study in med school are now potentially druggable!

www.nejm.org/doi/full/10....

From Dr. Paul Sax’s NEJM blog (HIV and ID Observations): when the question isn’t “What do the guidelines say?” but “What would you actually do?”

Read the blog here: blogs.nejm.org/hiv-id-obser...

#InfectiousDiseases #NEJM #theMednet

Bad sleep made woman's eyelids so floppy they flipped inside out, got stuck https://arstechni.ca #obstructivesleepapnea #floppyeyelidsyndrome #eyelids #Health #sleep #NEJM #eye

#NurseSky #MedSky #NEJM

Scimanuscript

🏛️ The 1820s. Two continents. Two journals. Two philosophies.
Both are still publishing, but they emerged from fundamentally different origins: one as an agent of disruption, the other as a pillar of consolidation.
🧵👇
#MedicalHistory #TheLancet #NEJM #Scimanuscript

Policies to screen doctors’ fitness seen lacking in fairness - UW Medicine - Newsroom

#NEJM paper recommends changes to improve fairness of screening programs required for late-career doctors. Thomas Gallagher @uwbioethics.bsky.social is a coauthor. @uwmedicine.bsky.social @uwdeptmedicine.bsky.social #aging

DynaMed Revolutionizes Clinical Decision Making with Same-Day NEJM Access DynaMed enhances clinical decision-making by offering same-day access to New England Journal of Medicine summaries, improving patient care.

DynaMed Revolutionizes Clinical Decision Making with Same-Day NEJM Access #United_States #Ipswich #NEJM #EBSCO #DynaMed

Dans un essai parrainé par #JandJ publié dans le #NEJM, une combinaison d’#immunothérapie expérimentale a permis de maintenir plus de 80 % des patients vivants et sans progression près de trois ans.
Thérapie standard ?
Environ 30 %.

I want to thank my co-authors Hélène Eltchaninoff, Elaine Tseng & Vinod Thourani, who argue pros and cons for this interesting vignette in our latest #NEJM Clinical Decisions. Read the full discussion below and cast your vote. @nejm.org @ai.nejm.org

High-Dose Influenza Vaccine to Reduce Hospitalizations | NEJM

✨ Recently published: Among adults aged 65–79 in the GALFLU trial (n=103,169), the high-dose inactivated influenza vaccine appeared to be associated with fewer hospitalizations for influenza or PNA compared with the standard dose. #NEJM

www.nejm.org/do/10.1056/N...

Molecular Evidence of Multiorgan Damage in Patients with Immune-Related Adverse Events | NEJM In 6 of 14 patients receiving immune checkpoint inhibitors, cell-free DNA methylation profiling revealed multiorgan damage with immune-related adverse events, often before symptoms appeared.

New #NEJM report led by Yuxuan Wang
In collaboration with Bert Vogelstein and my lab:
nejm.org/doi/full/10....
➡️ctDNA methylation profiling of blood can identify patients with irAEs
➡️irAEs often involve multiorgan tissue injury

Trastuzumab Deruxtecan in Residual HER2-Positive Early Breast Cancer | NEJM Patients with human epidermal growth factor receptor 2 (HER2)–positive early breast cancer and residual disease after neoadjuvant therapy are at high risk for recurrence. In a phase 3, open-label, ...

📢 Hot from the Press: Now published in #NEJM!

We are excited to share that the pivotal DESTINY-Breast05 data „Trastuzumab Deruxtecan in Residual HER2-Positive Early Breast Cancer“ presented by Sibylle Loibl at #SABCS2025, is now available.
🔗 Read the full NEJM article:
www.nejm.org/doi/full/10....

Wellcome #NejmClinician !

NEJM Clinician — Finding the Medicine That Matters in an Age of Infinite Evidence

www.nejm.org/doi/full/10....

@nejm.org
#CardioSky #nejm

A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia | NEJM Adjunctive glucocorticoids may reduce mortality among patients with severe community-acquired pneumonia (CAP) in well-resourced settings. Whether these drugs are beneficial in low-resource settings...

In the SONIA trial, adjunct low-dose glucocorticoid use in patients hospitalized with CAP in a low-resource setting was associated with lower 30-day all-cause mortality compared with standard care. #NEJM

www.nejm.org/doi/full/10....

Selective Decontamination of the Digestive Tract during Ventilation in the ICU | NEJM Whether selective decontamination of the digestive tract (SDD) reduces mortality among patients undergoing mechanical ventilation and whether it adversely affects microbial ecology in the intensive...

Among mechanically ventilated patients, selective digestive decontamination did not reduce in-hospital mortality compared with standard care. #NEJM #PITB #SuDDICU

www.nejm.org/doi/full/10....

🚨 New Trial Alert!
Atacicept shows a significant reduction in proteinuria in IgAN at 36 wks.
Fresh from #NEJM and highlighted for #KidneyWeek!
📊🧬🩺nejm.org/doi/full/10.10…
@hswapnil.medsky.social @kidneyboy.bsky.social @brianrifkin.bsky.social @jmteakell.bsky.social @nephroseeker.medsky.social

Finally, my warmest thanks to the CRICS-TriggerSep Scientific Board for their crucial role in designing and conducting this trial.

https://www.nejm.org/doi/full/10.1056/NEJMoa2502136

#EVERDAC #CriticalCare #ESICM2025 #NEJM #ICU #Research #CRICSTriggerSep

PinkOctober – Research Brings Hope: #INSEMA Study #GBG75

📖 Most recent results have been published in #NEJM: www.nejm.org/doi/full/10....

Exciting news: the latest INSEMA data will be presented as an Oral Presentation at the San Antonio Breast Cancer Symposium #SABCS2025 this December.

Our #NEJM Gaza commentary can be found here. Reminder: Some prominent physicians, other healthcare workers, remain imprisoned without charge, under harsh conditions. Gaza itself lies in ruins: its health system barely functions, essential supplies scarce
www.nejm.org/doi/full/10....

Where was Israel's medical establishment during the two years of atrocities in Gaza? | Opinion ***

Where was Israel's Medical Establishment? Dr Tamari, an NYC Israeli oncologist, dissects some of the angry responses in Israel to our recent #NEJM commentary about Gaza & ends with a harsh indictment of Israel's health establishment
powerful. simple. true.
#MustRead
www.haaretz.com/opinion/2025...

Tranexamic Acid in Patients Undergoing Noncardiac Surgery | NEJM Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. We conducted a trial involving patien...

The ground-breaking #NEJM #randomizedTrial suggests that every #surgery patient at substantial #bleeding risk should receive #tranexamicAcid: 24% #RelativeRisk reduction in serious bleeding.

www.nejm.org/doi/full/10....

Dr Booth presenting the #CCTG #CO21 #CHALLENGE trial to the GI tumours group at #ESMO2025 - the study was recently published in #NEJM www.nejm.org/doi/10.1056/...

Standing by Our Colleagues in Gaza — A Plea to the U.S. Medical Community | NEJM In the face of Israel’s ongoing assault on Gaza’s health system and the catastrophic famine caused by the devastation, U.S. physicians have an ethical obligation to respond and support immediate ch...

Finally, the NEJM allows true and factual reporting about the genocide in Gaza to be published. Hopefully, the Zionazi backlash doesn’t suppress the truth further than it has been!

#FreePalestine
#NEJM

Apixaban for Extended Treatment of Provoked Venous Thromboembolism. #NEJM

"Low-intensity therapy with apixaban for 12 months resulted in a lower risk of symptomatic recurrent VTE than placebo, with a low risk of major bleeding."

www.nejm.org/doi/full/10....

Apixaban for Extended Treatment of Provoked Venous Thromboembolism | NEJM The appropriate duration of anticoagulation for venous thromboembolism (VTE) in patients who have a transient provoking factor (e.g., surgery, trauma, or immobility) and concomitant enduring risk f...

🔑 HI-PRO Trial (NEJM): In pts w/ provoked VTE + enduring risk factors, 12 mo of low-dose apixaban ↓ recurrent VTE (1.3% vs 10%) vs placebo, w/ low major bleed risk. www.nejm.org/doi/full/10.... #VTE #Thrombosis #NEJM

Medical Imaging and Pediatric and Adolescent Hematologic Cancer Risk | NEJM Assessing the risk of radiation-induced hematologic cancer from medical imaging in children and adolescents might support informed decisions on the use of imaging. We followed a retrospective cohor...

Medical Imaging and Pediatric and Adolescent Hematologic Cancer Risk. #nejm

"Our study suggests an association between exposure to radiation from medical imaging and a small but significantly increased risk of hematologic cancer among children and adolescents."

www.nejm.org/doi/full/10....