Single-cell transcriptomics reveals distinct chondrocyte subpopulations and mechanisms driving osteoarthritis pathogenesis.
#SingleCellRNAseq #Chondrocytes #Osteoarthritis #Cartilage #CellHeterogeneity #OAPathogenesis
doi.org/10.1016/j.ge...

Researchers map a #singlecelltranscriptomic atlas of human #chondrocytes, identifying #apoptosis-prone hypertrophic cells and #osteoarthritis-expanded inflammatory #fibrochondrocytes, revealing altered differentiation trajectories.

#OpenAccess: doi.org/10.1016/j.ge...

Growth/Differentiation Factor 15 Promotes a Pro‐Regenerative Response in Chondrocytes Upon Cartilage Injury After cartilage injury, oxidative stress results in a posttraumatic cell fate decision: Intracellular ROS accumulation initiates a p53-dependent stress response in chondrocytes, including the transcr...

#Article in #MedComm
Growth/Differentiation Factor 15 Promotes a Pro-Regenerative Response in Chondrocytes Upon Cartilage Injury doi.org/10.1002/mco2..., studied by Dr. @janariegger.bsky.social and her group.

#CellFateDecision #chondrocytes #PTOA #GDF15 #PosttraumaticOsteoarthritis

#Melatonin restores Ca²⁺ homeostasis in Slc26a2-deficient #Chondrocytes, highlighting its potential as a novel treatment for SLC26A2-related #Chondrodysplasias. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Load activated FGFR and beta1 integrins target distinct chondrocyte mechano-response genes In response to mechanical stimuli, chondrocytes adapt their transcriptional activity, thereby shaping the cellular mechano-response; however, it remai…

Super happy to share that the first paper from my postdoc project is now available online! 🥳

#ExCarBon #FOR2407
#matrixbiology #chondrocytes #mechanobiology

www.sciencedirect.com/science/arti...

A study by Zhao et al. explored the function of endoplasmic reticulum (ER)-resident selenoprotein M (SELM) in #cartilage-forming #chondrocytes, investigating how SELM participates in cartilage ECM metabolism and ER stress modulation.
Learn more 🤓 https://buff.ly/3EJA34X

The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes - Nature Metabolism Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.

RESEARCH | S Loopmans, @geertlab.bsky.social et al. (KU Leuven):

The pentose phosphate pathway in #chondrocytes provides reducing power to ensure proteostasis necessary for #bone lengthening 🦴 🐁

https://bit.ly/3X1RuDS

#Fasting activates optineurin-mediated #mitophagy in #chondrocytes to protect against osteoarthritis
www.nature.com/articles/s42...

The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.

Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)