Managing adults with screen-detected islet autoantibody positivity: a pragmatic framework New disease-modifying therapies, such as teplizumab, offer opportunities to delay the clinical onset of type 1 diabetes but require islet autoantibody screening to identify individuals at increased ri...

In adults with #islet #autoantibody positivity, the lower risk of progression to type 1 #diabetes compared with children, combined with the high background prevalence of mild non-autoimmune dysglycaemia, presents substantial challenges for clinical management www.thelancet.com/journals/lan... #T1D

PTM BIO supported this discovery with lactylation and histone antibodies, including:
PTM-1401RM L-Lactyllysine, PTM-1419RM H3K9la, PTM-1001RM Histone H3, PTM-1424RM H2BK16la, PTM-1414RM H3K14la, PTM-1406RM H3K18la, and others.
#RheumatoidArthritis #Lactylation #Epigenetics #Autoantibody #PTMBIO

Dynamic control of autoreactive B cells from spontaneous germinal centers Abstract. Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled

academic.oup.com/jimmunol/adv...
“Dynamic control of autoreactive B cells from spontaneous germinal centers” 🐭
#SLE #lupus #autoantibody

#Medsky🧪 #IDsky #immunosky #publichealth A review the mechanisms through which #autoimmune responses can arise during & after 🦠 infection, focusing on the evidence for #Bcell dysregulation & #autoantibody in #longCOVID.

www.sciencedirect.com/science/arti...

www.sciencedirect.com/science/arti...

Are you interested in learning about my company @oncimmune ? We perform multiplexed #autoantibody profiling in patients with autoimmune diseases, cancer or during infections. Ower partner @Luminex has featured in their recent spotlight video. youtu.be/llW67W0isL4?fe… via @YouTube

Viruses That Mimic Human Proteins May Be More Common than Previously Thought A screen of human-infecting viruses identified extensive examples of viral proteins that resembled human sequences, which could trigger autoimmune diseases like multiple sclerosis.

investigating virus tropism & capacity for replication found #SARSCoV2 molecular
mimicry & evidence for #Bcell dysregulation and #autoantibody production In #LC / #neurocovid sequelas

www.sciencedirect.com/science/arti...

studenttheses.uu.nl/bitstream/ha...

www.the-scientist.com/viruses-that...

Predictors of response to intravenous immunoglobulin in patients with dermatomyositis: the ProDERM study AbstractObjectives. The phase 3 ProDERM study demonstrated intravenous immunoglobulin (IVIg) was safe and effective in patients with dermatomyositis (DM).

Predictors of response to intravenous #immunoglobulin in patients with #dermatomyositis: the ProDERM study

💉IVIg was effective regardless of demographic features and #autoantibody status.
💉Higher cutaneous activity and/or #anti-TIF1-γ responded better

academic.oup.com/rheumatology...

rmdopen.bmj.com/content/11/1...
The same question has been on my mind lately because I’ve been seeing isolated anti-SSB Ab a few times🧐

“Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value “

#Sjogren #autoantibody #Rheumsky

Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination - Scientific Reports Scientific Reports - Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination

#MedSky🧪#IDSky #Publichealth #ImmunoSky Rare #Coagulopathy caused by #autoantibody to protein S #COVID19.

www.nature.com/articles/s41...

Pdf

Pdf

Previous studies had shown that fragments of #SARSCoV2 🦠 that linger(#Viralpersistence) in patients after the initial infection heals .These ‘tails’ of postacute infection syndromes (PAISs) can cause chronic inflammation #autoantibody development
www.nature.com/articles/s41...

Study links severe COVID-19 to increase in self-attacking... A study spearheaded by Stanford researchers indicates tha...

In many cases of severe #COVID19, #autoantibody levels were similar to what you’d see in a diagnosed #autoimmune disease.”med.stanford.edu/news/all-news/2021/09/co...