Early insulin therapy and cardiovascular outcomes in newly diagnosed T2D
Real-world evidence linking early insulin intervention with improved cardiovascular outcomes in type 2 diabetes.
doi.org/10.1038/s413...
#InsulinTherapy #CardiovascularDisease #Type2Diabetes #ClinicalOutcomes

Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest Cyclic GMP-AMP synthase, cardiac arrest, cardiac dysfunction, return of spontaneous circulatio

This study finds that cGAS inhibition preserves #Mitochondrial integrity, reduces #OxidativeStress/#Apoptosis & enhances #Cardiac function, pointing cGAS inhibition as a novel therapeutic approach to improve #ClinicalOutcomes in CA patients.

#OpenAccess: tinyurl.com/245t9xd7

New population-based data characterize trends and outcomes across cardiovascular-kidney-liver-metabolic health, highlighting the interconnected impact of multisystem disease on prognosis.
https://ow.ly/kaGu50Y1vbt

#CardioMetabolicHealth #PopulationHealth #MultisystemRisk #ClinicalOutcomes

Risk Factors of Enternal Nutrition Intolerance in Septic Patients: A Case-control Study

This retrospective study investigates early #NeurologicalImpairment in adult patients with #Sepsis, identifying key influencing factors to inform prevention and treatment strategies aimed at improving #ClinicalOutcomes. #medsky
Full article: link.springer.com/article/10.1...

Moving beyond the pill: Unlocking value through engaged, empowered, and educated patients Creating an environment where the patient is recognised as an active participant in their care journey is critical.

#beyondthepill #clinicaloutcomes #realworldpatientexperiences #patientengagement #patientadherence #patientactivation #patientsegmentation #SDoH #patientstories #patientvoices #patientengagementtoolkit #patientpopulations #PROs #marketaccess #pharmaceuticalindustry
zurl.co/xTIs4

🔗 Read more: bit.ly/ONCOnews15D-03

#ONCOnews #OncoAlert #OncEd #OncologyNews #FDAApproval #ProstateCancer #ClinicalOutcomes

Synapse: Your Connection to our MSK Authors.
Meet: Puneeth Iyengar
Research Focus: Radiation Oncology; Attending

Impact of a dedicated inpatient radiation oncology consult service on goal-concordant care
synapse.mskcc.org/synapse/work...

#RadiationOncology #InpatientCare
#ClinicalOutcomes

A routine blood test could help predict who benefits most from CAR T-cell therapy – BioNews Central Measuring a patient’s absolute lymphocyte count can help predict their response to CAR T-cell therapy for non-Hodgkin lymphoma, providing a practical tool to guide treatment decisions. ...

Measuring a patient’s absolute #LymphocyteCount can help predict their response to #CARTcelltherapy for #NonHodgkinLymphoma, providing a practical tool to guide #TreatmentDecisions.
#TherapyResponse #ClinicalOutcomes

In 2,392 critically ill patients, higher 5-day fluid balance was linked to rising mortality (13.5% → 38.8%), even after severity adjustment.

Read more here: www.cureus.com/articles/354...

#Cureus #CriticalCare #ICU #Sepsis #ClinicalOutcomes #MedSky

This systematic review evaluates financial outcomes of sepsis bundles across acute and subacute care, finding 66.7% showed cost reduction. More research is needed in RACFs and pediatrics #Sepsis #Healthcare #Research #ClinicalOutcomes https://ow.ly/x6oA50XlBMc

Chloride channel accessory 4 suppresses stem cell-like properties of colorectal cancer and enhances anti-PD-1 immunotherapy

This study examines how CLCA4 regulates remission and #stemness transformation in #ColorectalCancer, emphasizing that modulating stemness through CLCA4 can remodel the #TumorMicroenvironment and enhance #ClinicalOutcomes. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This recent review explores the molecular mechanisms underlying #PlatinumResistance in #OvarianCancer (PROC) and highlights emerging #therapeutic strategies with the potential to improve #ClinicalOutcomes in PROC. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

TMLEP appoints new chief executive Joining from RLDatix & Allocate Software, Martin Dew will lead TMLEP, scaling services globally to drive resilience within healthcare providers.

TMLEP has appointed Martin Dew as chief executive officer to succeed Oliver Maughan, who is stepping down after more than a decade.

#healthcare #patientsafety #clinicaloutcomes #consultancy #riskmanagement

healthcaretoday.com/article/tmle...

Survival Outcomes after Monitoring, Surgery, or Radiotherapy for Clinically Localized Prostate Cancer
An, M. H., Jung, M. et al.
Paper
Details
#ProstateCancerTreatment #ClinicalOutcomes #RadiotherapySurgeryMonitoring

Hello brains trust - can anyone point me to resources on power analysis of case-mix adjustment models, preferably with mixed effects?

I'm using simr in R - but I'm having trouble relating the examples to my application

#rstats #clinicaloutcomes #stats

Featured today by @MSKLibrary: Prematurity and Congenial Diaphragmatic Hernia: Revisiting Outcomes in a Contemporary Cohort dx.doi.org/10.1016/j.jp...

#Neonatology #Pediatrics #MedicalResearch #ClinicalOutcomes #EvidenceBasedMedicine

Most Long COVID Cases Persist Beyond 2 Years In a three-year follow-up study, fewer than 2% of long COVID cases reported resolution of symptoms, with vaccinated patients demonstrating significantly better physical and mental health outcomes.

Most long COVID cases persist beyond two years, with only 1.8% reporting full resolution. Vaccination was associated with better physical and mental health outcomes.
#LongCOVID #ClinicalOutcomes

Prognostic Implications of Degenerative Mitral Regurgitation on Eligibility for TAVI Transcatheter aortic valve implantation (TAVI) has emerged as the primary treatment strategy for severe symptomatic aortic stenosis (AS) in the older population (>75 years of age) with high-risk surgi...

Prognostic Implications of Degenerative Mitral Regurgitation on Eligibility for TAVI.

Read More: tinyurl.com/5erxnwr7

#EligibilityCriteria #CardiacFunctionAssessment #AorticStenosis #ClinicalOutcomes #Cardiology #CardioEd #CVIA #CVIAJournal @scienceopen.bsky.social

34-35 NHS - Calm from chaos As the cover so boldly suggests, we’re talking ‘women in pharma’. Progress, ambitions, direction, understanding and essence. Indeed, this edition focuses on the dimensions of difference that only wome...

#NHSdata #NHSEngland #DHSC #Integratedcareboards #NHS #NHSworkforces #superICBs #NHSRegions #LeadProviderModels #NHSbudgets #NHS10yearplan #populationhealth #NHSpathways #patientaccess #patientexperience #clinicaloutcomes #commissioning #NHSproviders
magazine.pharmatimes.com/collections/...

A slide with a photo of the speaker and the title of the talk

🎤 Keynote: Core Outcome Measures 🎤

Prof Jeffrey Krischer (University of South Florida) will deliver our keynote on Core Outcome Measures, shaping how rare disease trials define success. A session not to miss! #ClinicalOutcomes

📅 Register here: www.eventbrite.ie/e/...

Mastering KAM excellence: achieving meaningful growth from top accounts - PMLiVE By Aaron Bean

#keyaccountmanagement #KAM #KAMexcellence #patientjourney #payers #payors #customerinsights #Accountbasedselling #strategicKAM #marketcomplexity #clinicaltrials #valueproposition #engagementstrategy #clinicaloutcomes #patientpathways #strategicpartnerships #marketaccess
pmlive.com/pharma_thoug...

Featured today by @MSKLibrary: Evolving racial/ethnic disparities in AML survival in the novel therapy era

#AML #CancerDisparities #EquityInHealthcare #SurvivalRates #OncologyResearch #RacialDisparities #ClinicalOutcomes

ashpublications.org/bloodadvance...

@pennmedicine.bsky.social

#STATI
TCR-NP method analyzes TCR network properties to link them with clinical outcomes. 🧬 It prioritizes features, improving disease prediction. 💉

#clinicaloutcomes #propertydevelopment #outcomes
Details: maxapress.com/article/doi/...

Pitch simulation 🏁 Miist Therapeutics Miist Therapeutics is an innovative U.S. company focused on inhaled medicine, raising $7 million in seed funding. Targeting high-demand markets like migraines and smoking cessation, it aims for significant growth backed by notable investors. Its advanced inhalation technology positions it as a pioneering force in the healthcare industry, offering substantial returns for early investors.

Miist Therapeutics raises $7M: Advancing inhaled medicine innovation 💨

Utilizing cutting-edge inhalation technologies

#InhalationInnovation #HealthcareStartup #ClinicalOutcomes #Entrepreneurship

This image is a promotional graphic for a guest blog titled "MCI Core Outcomes Study: Interviewing the Experts" by Victoria Gabb, a Senior Research Associate at the University of Bristol. It features a photo of an elderly woman laughing joyfully during a conversation with a researcher, who is visible from behind and partly out of focus. The text highlights the series' focus on tracking the progress of research in developing core outcomes for Mild Cognitive Impairment (MCI). The Dementia Researcher logo is also displayed, signifying the platform hosting the series. This setup conveys a personal, engaging approach to discussing scientific research and its impact.

🗣️ From systematic reviews to expert interviews, follow @victoriagabb.bsky.social 's journey to define core outcomes in MCI research. Her latest blog post is a window into the intricate process. #DementiaResearch #ClinicalOutcomes

https://buff.ly/4gjYpPI

Commure Strengthens AI-Powered Healthcare with Memora Health Acquisition Commure, a leading healthtech company known for its innovative healthcare software, has announced the acquisition of Memora Health, a digital care navigation platform. This strategic move is set to en...

www.linkedin.com/pulse/commur...

Commure Strengthens AI-Powered Healthcare with Memora Health Acquisition

kstrategyand.com/digital-heal...

#Commure #MemoraHealth #Healthtech #ClinicalOutcomes #HealthSystems #PatientEngagement #MedTech #AIHealthcare#Humanteconomy #Humantec #KStrategyand

4/6 Initial particle sizing did not significantly affect symptomatic improvement:

- Menorrhagia (p=0.134)
- Pelvic Pain (p=0.598)
- Bulk Symptoms (p=0.151)

Results indicate comparable outcomes between different particle sizes.

#ClinicalOutcomes #Research

4/6 Key Findings:

✔️ 92% technical success in single session
✔️ 100% post-procedure endpoint success
✔️ 5% major amputation rate
🚫 No major device-related adverse events or deaths
⚠️ Distal embolization in 29% resolved with adjunctive measures

#ClinicalOutcomes #EndovascularTherapy

4/6 Results: Objective Outcomes

📈 62% reduction in lesion size
📈 77% change in echogenicity
📈 84% reduction in cystic spaces
📈 68% developed phleboliths

Important correlation between symptom improvement & cystic space reduction (94%).

#Radiology #ClinicalOutcomes

5/6 📌 Conclusion: Percutaneous interventions offer a potential alternative for effective management for portal vein CTO, promising technical & clinical success.

Read the full study: doi.org/doi:10.1186...

#PercutaneousRevascularization #PortalVein #ClinicalOutcomes