Depictions of the structure of CDK11-cyclin L-SAP30BP. Four cryo-EM densities are shown at the top, two molecules models at the bottom. CDK11 is green, cyclin L is purple, and SAP30BP is yellow.

Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation.
www.biorxiv.org/content/10.6...

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells Abstract. Transcription factor heat shock factor 1 (HSF1) orchestrates the cellular stress response, promoting malignant transformation, unchecked prolifer

HSF1 drives cancer stress resilience but is hard to target—clever screen identifies spliceosome helicase DHX8 as a druggable regulator of HSF1 splicing→HSF1 program gone, cancer loses stress defenses. Editor's Choice in NAR Cancer. #PrecisionOncology #Spliceosome academic.oup.com/narcancer/ar...

Delphine Pott (left) and Marco Incarbone (right) standing in front of a yellow wall and next to a window facade in an office building. Both are smiling.

Great talk by @delphinem-p.bsky.social from @geminiteamlab.bsky.social yesterday: “Hijacking the Plant #Spliceosome” on how alternative splicing drives #viral infection and #tomato fruit development 🍅

Thanks to our host @incavirus.bsky.social for organizing this insightful seminar! 👏

📣 New NAR Breakthrough article! 📣

🧬 Cells resist starvation through a nutrient stress splice switch 🧬

👉 Read the free full text here: lnkd.in/eeE8KM8i

#NARBreakthrough #RNAsplicing #YeastGenetics #Introns #Spliceosome

Excited to share that our work on the spliceosome and gene regulation is featured in La Vanguardia as part of the XIV Premio Vanguardia de la Ciencia! 🧬🧠

You can vote for our project (last day!):
👉 bit.ly/3T3gyYT
Read the article (ES):
📰 bit.ly/3TzsNN3

#RNA #Spliceosome #PrecisionMedicine

More evidence of #spliceosome involvement in #neurodevelopmental disorder 👇

doi.org/10.1038/s415...

Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates Cell Research - Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates

Hot and splicy 🔥 Check out spliceosome complexes under quality control by GPATCH1-DHX35! We establish C. Thermophilum as serious player when it comes to spliceosomes. Great collaboration between the Hurt, Jingdong Cheng, Fei Xavier Chen and Lührmann labs. rdcu.be/ebBAx #spliceosome #somelikeithot

Exciting to host Dr. Anthony Vella from UConn School of Medicine! His groundbreaking work on T cell regulation & RNA-binding proteins is shaping the future of immunology. The spliceosome is an emerging frontier—stay tuned! #Immunology #TCells #RNA #Spliceosome #AAASFellow

Mycobacterial PstP impairs host RNA alternative splicing by dephosphorylation of spliceosome RBMX at S189 During Mtb infection, the serine/threonine protein phosphatase PstP is secreted into host cells and directly dephosphorylate S189 on the spliceosomal RNA-binding motif protein RBMX. Dephosphorylated ...

Mycobacterial PstP impairs host #RNA alternative splicing by dephosphorylation of #spliceosome RBMX at S189 #iMetaOmics onlinelibrary.wiley.com/doi/full/10....
#inflammation #mycobacteria

Biologists discover a new type of control over RNA splicing RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut o...

Biologists discover a new type of control over #RNA #splicing

#spliceosome #U1 #snRNA #LUC7

phys.org/news/2025-02...

The minor spliceosome: Researchers reveal new structural insights into an essential RNA-protein complex In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome con...

The minor #spliceosome: Researchers reveal new structural insights into an essential #RNA-protein complex

phys.org/news/2025-02...

The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a...

The #spliceosome: An atomic-level look into how #cells avoid errors when manufacturing #mRNA.

phys.org/news/2025-02...

Connecting genotype and phenotype in minor spliceosome diseases A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

#Minor #Spliceosome #Disease

rnajournal.cshlp.org/content/earl...

Five Breakthroughs In 2024 That Laid A Foundation For Future Tech From transforming coal to computing with DNA to pharmaceutical manufacturing in space, these are the discoveries that will set the stage for the next decade’s technology.

What a way to start 2025! Our spliceosome blueprint has been recognized by @forbes.com as one of the “Top Five Breakthroughs of 2024”. Huge thanks to my colleagues and my mentor Juan Valcarcel at @crg.eu #Biotech #Spliceosome #RNA #Innovation
www.forbes.com/sites/alexkn...

Direct and indirect effects of spliceosome disruption compromise gene regulation by Nonsense-Mediated mRNA Decay Pre-mRNA splicing, carried out in the nucleus by a large ribonucleoprotein machine known as the spliceosome, is functionally and physically coupled to the mRNA surveillance pathway in the cytoplasm ca...

Nice work!
#Spliceosome #NMD #RNA

www.biorxiv.org/content/10.1...

How molecular motors start the spliceosome Scientists at the MPI-NAT in Göttingen and ICR in London have uncovered the step that switches on the spliceosome.

Scientists @mpi_nat & @ICR_London have uncovered the decisive step that switches on the #spliceosome – it is activated by two molecular motors. This could provide new approaches to improve potential #cancer drugs that target the splicing process. @Nature
https://www.mpinat.mpg.de/4467575/pr_2309

The comparison of @IBMB_CSIC researcher Josep Vilardell of his work on Molecular mechanisms of pre-mRNA splicing and the concept of a fantastic library.
#Science, #MolecularBiology, #spliceosome, #ciència, #ciencia, @CSIC
Image from the TV show "The Librarians"