Early #matrine intervention of gut #microbiota for type 2 diabetes prevention #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#T2D #microbiome

A portable device for probiotic counting and viability assessment based on microfluidic chip and image recognition A portable, low-cost system enables rapid (3 min), on-site quantification of viable probiotics using a microfluidic chip with a fluorescent biosensor and image recognition. It distinguishes live/dead...

A portable #device for probiotic counting and viability assessment based on #microfluidic chip and image recognition #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#probiotics #biosensor #microbiome

RTTAP: Empowering metatranscriptomic data analysis with a read‐based total‐infectome taxonomic solution Metatranscriptomic data analysis is a complex task due to its sheer volume and the need for sophisticated bioinformatics tools. To address this, we developed the Read-based Total-infectome Taxonomic ...

RTTAP: Empowering metatranscriptomic data analysis with a read‐based total‐infectome taxonomic solution #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #taxonomy #diversity

Distinctive metabolic disturbances associated with redox homeostasis, nervous and hormonal functions during gut microbial enrichment upon polystyrene microplastic exposure Microplastic-induced gut microbial enrichment was dominated by bacteria within Eubacteriales, correlated with the virome, and accompanied by colitis. The polyamine synthetic pathway was activated to ...

Distinctive metabolic disturbances associated with redox homeostasis, nervous and hormonal functions during gut microbial enrichment upon polystyrene microplastic exposure #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#Microplastics #microbiome #metabolomics #RedoxBiology #Environment

Multiomics integration unravels genotype‐microbiome interactions shaping the conjunctival transcriptome The effects of genotype and microbiome on molecular phenotypes, such as host gene expression, can vary interdependently. Through an integrative analysis of conjunctival multi-omics data from 120 pair...

#Multiomics integration unravels genotype‐microbiome interactions shaping the conjunctival transcriptome #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#transcriptome #MachineLearning #microbiome #Bioinformatics

Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation Overview of Gut Microbiota's Role in Aging and Potential for Genetic Manipulation. The relationship between gut microbiota and aging is complex, with significant implications for both health and dise....

Harnessing gut #microbiota for #longevity: Insights into mechanisms and genetic manipulation #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#microbiome #aging #SCFA

Global meta‐analysis reveals the drivers of gut #microbiome variation across vertebrates #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#antibiotics #diet

Integrated #omics revealed the altered colonic microenvironment after inhibition of peripheral serotonin synthesis by #LP533401 #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#serotonin #metabolomics #microbiome #vitamin

Saliva MicroAge: A salivary microbiome based machine learning model for noninvasive aging assessment and health state prediction Saliva MicroAge is a machine learning-based model designed to estimate biological age and assess health status using globally sourced salivary microbiome data. Trained on 4532 healthy samples, the mo...

Saliva MicroAge: A salivary #microbiome based machine learning model for noninvasive #aging assessment and health state prediction #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#MachineLearning #OralHealth

Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management Gut microbiota extracellular vesicles play (GMEVs) a vital role in maintaining the health of the digestive system and facilitating proper brain functioning. Gut dysbiosis exacerbates gut inflammation...

Emerging role of gut #microbiota extracellular vesicle in #neurodegenerative disorders and insights on their therapeutic management #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#inflammation #microbiome #GutHealth

Genome assembly and genomic architecture of a prominent cold‐resistant rapeseed germplasm The genomic landscape of cold-tolerant winter rapeseed (Brassica napus, L) has been poorly characterized. We assembled a high-quality reference genome of a prominent cold-tolerant winter rapeseed cul...

Genome #assembly and genomic architecture of a prominent cold‐resistant rapeseed germplasm #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #genome #phylogenetics #methylation

HiFi based metagenomic assembly strategy provides accuracy near isolated genome resolution in MAG assembly Recovering high-contiguity, circular bacterial genomes from complex microbiomes (e.g., gut) is challenged by limitations of short-read and error-prone long-read sequencing. This study comprehensively...

HiFi based metagenomic assembly strategy provides accuracy near isolated #genome resolution in MAG #assembly onlinelibrary.wiley.com/doi/10.1002/...
#iMetaOmics #microbiome #Bioinformatics #MAG

Electroacupuncture reshapes the microbial co‐occurrence networks related to the behavioral and psychological symptoms of dementia in Alzheimer's disease Microbial keystone species and gut microbiota composition are highly variable during the pathological development of the behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's diseas...

Electroacupuncture reshapes the microbial co‐occurrence networks related to the behavioral and psychological symptoms of dementia in #Alzheimer's disease #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#microbiome

Commentary on LRAs targeting NF‐κB with #epigenetic and mutational impacts on #HIV latency #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#methylation #epigenetics

Multi‐omics analysis of gut‐organ axes reveals the high‐altitude adaptation in Tibetan chicken The Qinghai-Tibet Plateau is an extreme ecosystem subject to special climatic conditions that require unique adaptations for its inhabiting organisms. In addition to genetic characteristics, the gut ...

Multi‐omics analysis of #gut‐organ axes reveals the high‐altitude adaptation in Tibetan #chicken onlinelibrary.wiley.com/doi/10.1002/...
#iMetaOmics #poultry #GutHealth #microbiome

TBCancer: A database for exploring characteristics and functions of tissue‐biased genes in cancer This study defined 10,921 tissue-biased genes across 54 normal tissues and 41 cancer types. Tumor-associated tissue-biased genes exhibit downregulation, mutations, and epigenetic modifications, corre...

TBCancer: A #database for exploring characteristics and functions of tissue‐biased genes in #cancer #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#scRNA #TME #immun

When the microbiome meets One Health principle: Leading to the Holy Grail of biology and contributing to overall well‐being and social sustainability Unveiling the microbiome as a cornerstone for interdisciplinary solutions to global health challenges, this theory integrates microbiome research with the One Health approach to develop innovative st....

When the #microbiome meets One Health principle: Leading to the Holy Grail of biology and contributing to overall well‐being and social #sustainability #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#OneHealth #ecology

OUTPOST: A comprehensive analysis software for whole‐metagenome shotgun sequencing incorporating group stratification The whole metagenOme shotgun seqUencing sTream Pipeline that is cOmprehensive and uSeful for mulTi groups experiments (OUTPOST) is a comprehensive analysis software for whole-metagenome shotgun seque....

OUTPOST: A comprehensive analysis software for whole‐metagenome shotgun sequencing incorporating group stratification #iMetaOmics
onlinelibrary.wiley.com/doi/10.1002/...
#metagenome #microbiome #Bioinformatics

Arabidopsis multiomics reveals the role of autophagy in root microbiome assembly Upon mutation of the core autophagy protein ATG5, disrupted autophagy pathways result in alterations in several biological processes important for plant-root microbe interaction mechanisms, including....

#Arabidopsis multiomics reveals the role of #autophagy in root #microbiome assembly #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...

Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs This study successfully established gut microbiota-humanized pigs, achieved human-like remodeling of the serum metabolome, and uncovered transcriptional alterations in immune cell subsets. These find....

#Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#FMT #metabolome

Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging In total, 822 facial microbial samples and 14 skin phenotypes were assessed in a Chinese cohort. We profiled skin microbiome dynamics associated with age and skin aging phenotypes. Using machine lear...

Culture dependent and independent approaches reveal the role of specific #bacteria in human #skin #aging #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#microbiome

BioMGCore: A toolkit for detection of biological metabolites in microbiome The keyword matching and gene proximity principles were used to accurately identify core gene clusters in microbial genomes. The metabolic gene clusters can be classified into different taxonomic gro...

BioMGCore: A toolkit for detection of biological metabolites in microbiome #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #microbiome #metabolism

CPStools: A package for analyzing chloroplast genome sequences CPStools is a user-friendly software for comprehensive chloroplast genome analysis. It integrates 10 functionalities including Genbank file checking, statistical information generation, sequence adju...

CPStools: A package for analyzing #chloroplast genome sequences #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #plants

Impact of dietary live microbes and nondietary prebiotic/probiotic intake on #osteoarthritis and rheumatoid arthritis development: Stratified findings from NHANES data #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#RheumatoidArthritis #diet #prebiotics #prebiotics

Leveraging genetic data for female breast cancer prevention and therapy: Perspectives from Mendelian randomization Leveraging genome-wide association studies, Mendelian randomization analysis has been applied to explore the potential causal associations between various risk factors and female breast cancer, predi....

Leveraging genetic data for female breast #cancer prevention and therapy: Perspectives from Mendelian randomization #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #CancerResearch #BreastCancer

Role of soil microbes in enhancing crop heterosis Heterosis, or hybrid vigor, is characterized by the enhanced performance of F1 progeny in terms of yield, biomass, and environmental adaptation compared to their parental lines. Recent studies unders....

Role of soil microbes in enhancing #crop heterosis #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#microbiome #SoilHealth

Longitudinal profiling of the human gut microbiome reveals temporal and personalized responses to inulin This study monitored gut microbiome changes in healthy volunteers following inulin intervention, revealing dynamic and highly individualized shifts in microbial composition and short-chain fatty acid...

Longitudinal profiling of the human gut #microbiome reveals temporal and personalized responses to inulin #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#inulin #GutHealth #SCFA #microbiota #ecology

A glimpse into the future: Integrating artificial intelligence for precision HER2‐positive breast cancer management This review provides a systematic overview of existing AI studies related to anti-HER2 therapies in breast cancer (BC). It delves into three key domains of artificial intelligence (AI) research assoc...

A glimpse into the future: Integrating artificial intelligence for precision #HER2‐positive breast #cancer management #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#CancerResearch #AI #BreastCancer #MedTwitter #radiogenomics

Ocular microbiota types and longitudinal microbiota alterations in patients with chronic dacryocystitis with and without antibiotic pretreatment Two types of ocular microbiota and three types of nasal microbiota were demonstrated among ocular diseases patients. Although clinical recovery is comparable, the antibiotic pretreatment significantl...

Ocular #microbiota types and longitudinal microbiota alterations in patients with chronic #dacryocystitis with and without antibiotic pretreatment #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#microbiome #antibiotics #EyeHealth

Dual‐pronged genome engineering: Enhancing crop resistance through elite allele pyramiding and susceptibility gene editing Developing durable crop disease resistance remains a primary breeding objective, achievable through pyramiding resistance genes and editing susceptibility (S) genes. A recent study identified 10 stab...

Dual‐pronged #genome engineering: Enhancing #crop resistance through elite allele pyramiding and susceptibility gene editing #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#CRISPR #GeneEditing #cotton