🦺 Safety Alert!🦺
While each jobsite may have different PPE rules - when it comes to splicing fiber optic cabling, it is crucial to protect yourself.
Safety Shields✅️
Gloves✅️
Discarding of Glass Shards✅️
www.bridgecable.com/cabling-safe...

#fiberopticcabling #fibersplicing #splicing #fiberexperts

Original post on mastodon.social

`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single […]

Species phylogeny, genomic and transcriptomic data, and Ne proxies used in the present study. Left: Phylogenetic tree of the 100 metazoan species considered. Middle: Available genome and transcriptome datasets of each species concerned, including CAGE-seq, 3′-end-seq, RNA-seq, coding genes, and BUSCO genes. Right: Ne and proxies.

What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @plosbiology.org 🧪 plos.io/3Pcs2e6

Species phylogeny, genomic and transcriptomic data, and Ne proxies used in the present study. Left: Phylogenetic tree of the 100 metazoan species considered. Middle: Available genome and transcriptome datasets of each species concerned, including CAGE-seq, 3′-end-seq, RNA-seq, coding genes, and BUSCO genes. Right: Ne and proxies.

What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @plosbiology.org 🧪 plos.io/3Pcs2e6

Species phylogeny, genomic and transcriptomic data, and Ne proxies used in the present study. Left: Phylogenetic tree of the 100 metazoan species considered. Middle: Available genome and transcriptome datasets of each species concerned, including CAGE-seq, 3′-end-seq, RNA-seq, coding genes, and BUSCO genes. Right: Ne and proxies.

What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @plosbiology.org 🧪 plos.io/3Pcs2e6

The AFL SpliceConnect Tool Kit offers a quick, cost-effective alternative to #fusionsplicing. Using V-groove technology, it keeps fibers in physical contact for
Learn more: https://bit.ly/4cD9BJ5

#FiberOpticCenter #fibersplicing #splicing

New insights into microbial manipulation of the plant spliceosome Abstract. Alternative splicing (AS) has emerged as a regulatory layer in plant adaptation to the environment. In particular, biotic stresses trigger a dras

In our recent review, we explore how the spliceosome is targeted by effectors from diverse plant-interacting organisms—and how these effectors can serve as powerful molecular probes to uncover the mechanisms of splicing regulation in plants.

@geminiteamlab.bsky.social

#PlantScience #RNA #Splicing

Excited to see this project get the underway. I am looking forward to working with Thomas Duchaine, @bcmagog.bsky.social & industry partners to develop new #RNA_Therapeutics targeting #splicing defects for neurological and tare diseases through our complementary biomanufacturing platforms.

Xinlai Cheng gave an interesting talk at #Biochemistry2026. He talked about his group's research into "Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation".

onlinelibrary.wiley.com/doi/10.1002/...
#Splicing #Biochemistry #ChemSky #ChemBio

Splicing training part two
#splicing #ropes #sailing

Targeted blocking of gene splicing can dysregulate intron-embedded primary microRNAs - Communications Biology Splice-site targeting antisense oligonucleotides can increase the expression of host gene intron-embedded microRNA and affect axonal development in zebrafish.

🐟 Studying #zebrafish pituitary development, researchers show that ASO-induced suppression of gene #splicing leads to the dysregulation of intronic primary #microRNAs.
www.nature.com/articles/s42...

RNA Splicing Lab - JOIN US Are you interested in investigating basic mechanisms in splicing regulation and gene expression? Our research group was launched in September 2024 and is hosted at the Institute of Molecular Infection...

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us
Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! 🧪🧫

🎨 Reposting these with Alt Text for each character~

#sprites #splicing #ocs #gymleaders #elitefour #professor #pokemon

Do you want to understand how RNA #splicing decisions are made? We‘ve got a PhD position open for you (see 👇👇)!!
Please share #RNAsky and RT!

tinyurl.com/4ztu9cb9

Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics Nature Communications - Alternative splicing generates diverse protein isoforms, yet the functions of most exons remain unknown. Here, the authors introduce scCHyMErA-Seq, a scalable single-cell...

We’re excited to introduce scCHyMErA-Seq, a scalable #CRISPR-based #exon-deletion screening platform with #single-cell transcriptomic readouts, enabling high-throughput functional analysis of #alternative #splicing. In collaboration with the Gonatopoulos-Pournatzis lab. @natcomms.nature.com

We analyzed 17 BRCA1 and BRCA2 variants associated with hereditary breast and ovarian cancer to evaluate their impact on RNA splicing. Eight variants showed aberrant splicing, while nine had no spliceogenic effect, enabling improved variant classification. 🔬 This work contributes to refining the clinical interpretation of BRCA1 and BRCA2 variants and highlights the importance of combining experimental and computational evidence for genetic risk assessment. https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvaf177/8416539. https://doi.org/10.1093/clinchem/hvaf177. Epub ahead of print. PMID: 41499258.

✨ We are starting the year with great news! 🎉 Our new paper titled "Splicing predictions, splicing assays and variant classification using ACMG/AMP guidelines: challenges observed with BRCA1 and BRCA2 variants" has been published. 🧬
#Genetics #BRCA #HereditaryCancer #Splicing #ACMG #Research