#DNADamageResponse protein, KIN, drives #ESCC progression by clearing R-loop–associated #DNAdamage, while KIN depletion triggers NFκB–STING activation, improves the #TumorImmuneMicroenvironment, and enhances #immunotherapy response.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Recent research introduces the CIN score, a novel gene signature in #BreastCancer that predicts prognosis, #TumorImmuneMicroenvironment, and drug responsiveness, offering insights that guide precision #Immunotherapy strategies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Ultra-high dose rate #radiotherapy overcomes #radioresistance in #HeadAndNeckCancer by inducing #DNAdamage and activating a CD8+ T cell–M1 #macrophage feedback loop, enhancing the #TumorImmuneMicroenvironment for improved therapeutic outcomes.

#STTT: doi.org/10.1038/s413...

This latest review explores how #CellCycle regulatory proteins shape the #TumorImmuneMicroenvironment and emphasizes that targeting them could unlock new #Immunotherapy strategies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study elucidates the dual role of ultra-high dose rate radiotherapy in directly inducing #DNADamage and modulating the #TumorImmuneMicroenvironment, highlighting its potential in treating radioresistant #HNSCC. #medsky

Read more in #STTT #OpenAccess: doi.org/10.1038/s413...

This review summarizes recent studies on the effects of #cellcycle regulatory proteins on #antitumor immunity through the regulation of the #tumormicroenvironment (TME) and examines the underlying regulatory mechanisms. #TumorImmuneMicroenvironment #medsky

#OpenAccess: buff.ly/IVLBa5H

#CancerSky #ImmunoSky #MedSky

#Cancer #Aging #Metabolism

#TIME to Watch you Eat'

#Age- & #Diet- instructed Metabolic Rewiring of the #TumorImmuneMicroEnvironment

#TIME-ly review from @unil.bsky.social authors now breaking at @jem.org

rupress.org/jem/article/...