Graphical abstract illustrating ARSI-induced lineage plasticity in prostate cancer. Androgen receptor signaling inhibition promotes transition from prostate adenocarcinoma (PRAD) to aggressive CRPC variants with increased mesenchymal, basal, stem-like, and neural cell states, highlighting reversibility and tumor heterogeneity.

📘 CHP Archive Spotlight #05
Perspective (2024) | Jamroze, Liu & Tang
AR signaling inhibitors induce lineage plasticity in prostate cancer, promoting stem-like, mesenchymal & neural states driving CRPC & NEPC progression.
🔗 doi.org/10.47248/chp...
#LineagePlasticity #CRPC #CancerStemCells

🚀From Bench to Paper | Nature: Basal cells = origin of tuft-like SCLC, explaining NE–tuft plasticity & heterogeneity.
💡MedChemExpress’s Y-27632 (ROCK inhibitor) supports basal cell culture & plasticity models.
#CancerResearch #SCLC #LineagePlasticity

Great talk by Wouter Karthaus at the #EACR2025 on uncovering resistance mechanisms in castration-resistant prostate cancer. Impressive use of organoids to study lineage plasticity. Lifting the veil on resistance mechanisms #CancerResearch #Organoids #LineagePlasticity