As usual, we've had a great time presenting our projects at the 7th Central German Meeting on #Bioinformatics - Mittelerde Meeting 2026 at @unihalle.bsky.social! 🧬⚕️🦠🌡️🔧🖥️
Thanks to the organizers and sponsors!
#epigenomics #diagnostics #methylation #ncRNA #adaption #Sugar #DataEngineering #metadata

Schematic overview of noncoding RNA functions in cancer cell plasticity. The figure is organized by RNA type: miRNAs regulate pluripotency inhibition, translational repression, mRNA degradation, EMT transition, cancer stem cell initiation, and metastasis; lncRNAs modulate epigenetic regulation, transcription, signaling pathways, chromatin architecture, alternative splicing, and dedifferentiation; circRNAs function as miRNA sponges, regulate transcription, interact with RNA-binding proteins, and influence self-renewal and apoptosis; tRNAs and tRNA-derived fragments regulate translation, mRNA stability, mitochondrial homeostasis, metabolic reprogramming, and hormone-dependent signaling.

Illustration of therapeutic strategies targeting noncoding RNAs in cancer. Approaches include synthetic miRNA mimics and lentiviral delivery for oncogene suppression, antisense oligonucleotides and RNA sponges for tumor suppressor restoration, CRISPR-based activation or repression of lncRNAs, synthetic circRNA sponges and Cas13-mediated cleavage, siRNA-loaded nanoparticles, and inhibition of tRNA methyltransferases to block translation and tumor growth.

📘 CHP Archive Spotlight #07
Review (2024) | Her et al.
How do noncoding RNAs drive cancer plasticity?
miRNAs, lncRNAs, circRNAs & tRNA fragments regulate stemness, EMT, epigenetics & therapy resistance — with emerging roles as biomarkers & targets.
🔗 doi.org/10.47248/chp...
#ncRNA #CancerStemCells

This study explores the biosynthesis and functions of snoRNAs, piRNAs, tsRNAs, and circRNAs in #HeartFailure and ischemic disease, highlighting strategies for translating #ncRNA research into novel clinical applications.

#OpenAccess: doi.org/10.1016/j.ge...

RNAcentral in 2026: genes and literature integration Abstract. RNAcentral was founded in 2014 to serve as a comprehensive database of non-coding RNA sequences. It began by providing a single unified interface

From the @rnacentral.bsky.social team in the @narjournal.bsky.social #NARDatabaseIssue | RNAcentral in 2026: genes and literature integration | #Bioinformatics #Database #OpenScience #Genomics #RNA #ncRNA 🧬 🖥️🧪🔓
⬇️
academic.oup.com/nar/advance-...

Predicting ncRNA-Protein Interactions with a Graph Attention Model Exploiting Personalized Subgraphs.
Khoushehgir, Fatemeh et al.
Paper
Details
#ncRNA #ProteinInteractions #GraphAttention

Open Public Resource in R2: The RNA Atlas, the most complete #mRNA resource assessed in 300 tissues / cell types. Explore it for yourself at:

r2platform.com/rna_atlas/

#science #Datavisualization #transcriptome #ncRNA

📑 New Review for your reading list

Cis-regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

🔓 buff.ly/g5WeXxC

@Dr_Alex_Eustace #ncRNA #BCSM #Biomarkers

Here you can see a cryoEM structure of the Clostridium botulinum OLE non-coding RNA (PDB code: 9LCR)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #ncRNA #clostridium #sensor #OLE #cryoem

Open Public Resource in R2: The RNA Atlas, the most complete #mRNA resource assessed in 300 tissues / cell types. Explore it for yourself at:

r2platform.com/rna_atlas/

#science #Datavisualization #transcriptome #ncRNA

RNAcentral in 2026: Genes and literature integration. #nonCodingRNA #ncRNA #Genomics @biorxiv-bioinfo.bsky.social
www.biorxiv.org/content/10.1...

Maria had a great time at the Microbes & RNA 2025 Meeting in #Strasbourg where she presented her #poster about #SweetSynteny, a #nextflow pipeline for nonambiguous identification of #ncRNA paralogues 👏🦠🧬📊 #MicrobialRNAs #conference

🍂 Our September Issue is out🍁

📣 This “In the Limelight” issue features Review articles on non-coding RNAs in cancer, as introduced by Guest Editor Marcin Majka

🖱️ Access it here
🔓https://buff.ly/Ay5RGfz

#RNAbiology #NoncodingRNA #ncRNA #Oncology #CancerResearch

Program – Microbes & RNA 2025

Learn more about #SweetSynteny, a #nextflow pipeline for nonambiguous identification of #ncRNA paralogues
– Visit #poster WE-41 of our doctoral researcher Maria at the Microbes & RNA 2025 Meeting in #Strasbourg tomorrow! #MicrobialRNAs #conference 🦠🧬🇫🇷
microbialrnameeting.com/program/

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"The 21st century, Thomas Cech says, 'is the age of noncoding RNA.'"

We agree with Dr. Cech. Since ncRNAs can be long, structured, and modified, they’re often tricky to characterize.

So, we developed the solution: a next-generation RT, UltraMarathonRT.

#RNASky #RNA #ncRNA #noncodingRNA

‪So proud we could take part in this amazing project!
Germline/meiosis crowd, you must check this out. A whole new dimension of non-cell autonomous control on gametogenesis.
Also, triple shoutout for @ethanewe.bsky.social . A great PI on the way
#meiosis #germline #ncRNA

🧪 Happy Worldwide RNA Day!🎉
Aug‌ust 1 is RNA Day, a global moment to recognize ribonucleic acid’s central role in science. AUG, universal “start” codon launches protein synthesis, making it a fitting anniversary for molecule starting so much discovery.🦠💉🔬 #RNA #ncRNA #miRNA @rnasociety.bsky.social

Happy #WorldRNADay! 🎉We mark the occasion with an exclusive first look at the cover of our upcoming special issue on 'Non-Coding RNAs in Cancer'🧬🎗️

Stay tuned for the full release in September! 🙌

#ncRNA #cancerresearch #academictwitter

@rnasociety.bsky.social

OLE RNA dimers are depicted as integral membrane noncoding RNAs. This bacterial complex appears to penetrate membranes and mitigate cellular stresses. #ncRNA #RNAWorld @ronbreaker.bsky.social @yalembb.bsky.social bit.ly/3FVn5Cd

Here you can see a crystal structure of the hnRNPA1 and telomere-related TERRA RNA complex (PDB code: 8X0N)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #telomere #terra #ncRNA #aging #hnRNPA1 #xray

SMDesigner automates the generation of mutations to assess predicted secondary structures and functions of conserved RNA structures based on sequence alignments. #ncRNA #RNA structure bit.ly/3Fl7yet

Here you can see a very recent cryoEM structure of raiA ncRNA showing a new 3D structure folding (PDB code: 9G7C)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #ncrna #folding #clostridium #stress #cryoem

#RNAsky #ncRNA #microRNA

Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach - Nature Communications Human pathways acting on nuclear ncRNAs have been refractory to forward genetics. Here, the authors develop a forward genetic approach that identifies such pathways and show DDX59 is required for mino...

A tour de force. Wonderful stuff! Congrats!
#ncRNA #MALAT1 #RNAExosome #RNaseP #NEXT #DDX59 #RNADecay #RNA #RNAsky

www.nature.com/articles/s41...

Wonderful Research In Progress update by NIH T32 Fellow, Jonah Zarrow, on developing novel #ncRNA drugs for #Duchenne muscular dystrophy. Important work for #DMD!

@eduardomarban.bsky.social
@smidtheart.bsky.social
@mda.org

GL4SDA: Predicting snoRNA-disease associations using GNNs and LLM embeddings. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.03.014

🧬 Ready for AI to crack the RNA-disease code?

🔗 GL4SDA: Predicting snoRNA-disease associations using GNNs and LLM embeddings. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#AIinBiomedicine #LLM #ncRNA #snoRNA #PrecisionMedicine #Genomics

Preclinical Study: After Heart Attack, a Boost in Anti-Inflammatory Cells Promoted Healing A scientific technique that rapidly increases the body’s production of anti-inflammatory cells promoted healing from heart attacks in mice, according to a new study by investigators from the Smidt Hea...

Recent paper published in @jclinical-invest.bsky.social from @eduardomarban.bsky.social & Ke Liao finds a #ncRNA that enhances #Treg cells that could potentially repair heart muscle damage after a #HeartAttack & be applied to a variety of inflammatory disorders.
www.cedars-sinai.org/newsroom/pre...

Check out the in-press preview of our @jclinicalinvest paper on regulatory #Tcells — we discovered a #ncRNA that can enhance #Treg dynamics fast enough to improve #MI healing in vivo. New hope for refractory inflammatory and immune conditions?
🔗 www.jci.org/articles/vie...

@russellrogers.bsky.social discussed experiments w/Lefer Lab taking advantage of the mechanistic differences between #GLP1RA & #ncRNA #TY1 as therapeutics for #HFpEF. Compelling evidence for synergistic benefits in two rodent models! Potential for less skeletal muscle loss?
@smidtheart.bsky.social

Had a great time at the 75th anniversary meeting of the Muscular Dystrophy Association discussing our work on #ncRNA in #Duchenne MD. Honored to be a recognized as a grant recipient of MDA to study cell-free therapies for #DMD.

@mda.org @eduardomarban.bsky.social @smidtheart.bsky.social

Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis Nuclear RNA homeostasis depends on the balance of transcription, RNA processing, degradation, and transport between the nucleus and cytoplasm. RNA degradation directed by the Integrator, nuclear exoso...

Interesting! #RNADecay #RNAExosome #RNA #ncRNA

Defining the roles of the #Integrator, #NEXT, and #nuclear #exosome complexes in #Drosophila #oogenesis
Yongjin Lee, Adriano Biasini, Cindy Tipping, Seong Hyeon Hong, Phillip Zamore

www.biorxiv.org/content/10.1...