Proud to share our latest preprint! 🥳
Using a multidisciplinary approach, we uncover a dual function of the snR37 H/ACA snoRNP - combining pseudouridylation with ribosome chaperone activity within a single RNP.🔬🧬
Challenging the traditional view of snoRNP function. 👇
#cryoEM #ribosome #RNA #snoRNA

snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice snoRNA Snord3-mediated epigenetic activation of ESM1 is a potential therapeutic target in rheumatoid arthritis.

Epigenetics Update - snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice bit.ly/47CYvRt

#snoRNA #Epigenetics #RheumatoidArthritis #Snord3
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High-resolution insights without cell sorting; epigenometech.com

GL4SDA: Predicting snoRNA-disease associations using GNNs and LLM embeddings. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.03.014

🧬 Ready for AI to crack the RNA-disease code?

🔗 GL4SDA: Predicting snoRNA-disease associations using GNNs and LLM embeddings. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#AIinBiomedicine #LLM #ncRNA #snoRNA #PrecisionMedicine #Genomics

SnoBIRD: A tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes Small nucleolar RNAs (snoRNAs), a group of noncoding RNAs present amongst all eukaryotes, are most extensively characterized for their regulation of ribosome biogenesis and splicing. Despite their cen...

#snoRNA ❄️ 🐦
www.biorxiv.org/content/10.1...

A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors - Nature Communications Small nucleolar RNAs (snoRNAs) are known for their role in RNA modification to regulate gene expression. Here, the authors identify a snoRNA that not only guides ribosomal RNA 2’- O-methylation but al...

Congrats! #snoRNA #pombe
www.nature.com/articles/s41...

RiboMod2025 RiboMod2025

RiboMod2025 Deadlines Approaching!
April 10, 2025 – Abstracts & Travel Fellowships Due!

What’s RiboMod2025?
A workshop on snoRNA & rRNA modification standards.
June 12-13, 2025 | Bologna, Italy

🔗 Apply Now: events.unibo.it/ribomod2025

Join us in Bologna! 🚀 #RiboMod2025 #snoRNA #rRNAmodifications

SNORD113–114 cluster maintains haematopoietic stem cell self-renewal via orchestrating the translation machinery - Nature Cell Biology Wang et al. profile the translatome of haematopoietic stem cells (HSCs) and downstream progenitors and lineages. They identify the SNORD113–114 cluster as a modulator of translation and self-renewal i...

#snoRNA
www.nature.com/articles/s41...

RiboMod2025 RiboMod2025

🚀 RiboMod2025 – Registration Now Open! 🎉

Join us in Bologna, Italy (June 12-13, 2025) for a landmark workshop on snoRNAs & rRNA modifications!
🔗 Register now: eventi.unibo.it/ribomod2025

#RiboMod2025 #RNA #snoRNA #rRNA #Biology #NonCodingRNA #MolecularBiology

RNase III cleavage signals spread across splice junctions enforce sequential processing of co-hosted snoRNAs Small nucleolar RNAs (snoRNAs) are a class of non-coding RNA molecules whose precursor transcripts are capped and polyadenylated. However, these end modifications are detrimental to snoRNA function an...

#RNaseIII #snoRNA #Spombe

www.biorxiv.org/content/10.1...

Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics

snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions, which facilitate nascent protein translocation to the ER and subsequent secretion.

www.cell.com/cell/fulltex...
#snoRNA #RNAsky #RNA