HMGCR inhibition reduces stemness & metastasis in HCC via Hedgehog signaling.
#HMGCR #HedgehogPathway #CancerStemCells #LiverCancer #Oncology
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This recent review integrates advances in #HMGCR biology with #therapeutic strategies, bridging mechanistic insights & #Translational challenges, & proposes redefining HMGCR targeting as a multifaceted paradigm in #PrecisionOncology. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling

This study uncovers the role of #HMGCR in maintaining #HepatocellularCarcinoma (HCC) stemness and promoting #metastasis through activation the #Hedgehogsignaling pathway and highlights the potential therapeutic value of #simvastatin for clinically suppressing HCC metastasis. #medsky

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