Systematic Discovery of Motif-based Interactions of the Auxiliary Domains of USP Family Deubiquitinases The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity i...

Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...

#Deubiquitinases (DUBs), key regulators of ubiquitin signaling, have been increasingly recognized for functions beyond rescuing substrate proteins from proteasomal degradation. Due to a lack of selective chemical tools within the DUB space, finding these functions has proven to be very challenging.

Enzyme trick allows bacteria to embed themselves permanently in host cells Working in collaboration with colleagues at the University of Leiden in the Netherlands, scientists at the University of Cologne's Institute for Genetics have discovered a strategy in bacteria by whic...

#Enzyme trick allows #bacteria to embed themselves permanently in #host_cells.

#ubiquitin_marking #deubiquitinases #evolutionary_arms_race

phys.org/news/2025-03...

This study has it all! A truly structure-to-function study on two #deubiquitinases that were thought to be pseudoenzymes and providing insights into disease mutations. Congratulations to @gallantkai.bsky.social, Kim and the team!