NEJM Editorial Fellow Katerina Lin, MD, explains a clinical trial in which the photovoltaic retina implant microarray (PRIMA) system restored central vision and led to a significant improvement in visual acuity. Read the full PRIMAvera trial results: nej.md/3KP9Jta

#MedSky #Ophthalmology

Social deprivation in neovascular age-related macular degeneration: when equal treatment does not deliver equal vision Eye, Published online: 04 April 2026; doi:10.1038/s41433-026-04423-2Social deprivation in neovascular age-related macular degeneration: when equal treatment does not deliver equal vision

Ophthopedia Update: Social deprivation in neovascular age-related macular degeneration: when equal treatment does not deliver equal vision: Eye, Published online: 04 April 2026; doi:10.1038/s41433-026-04423-2Social deprivation in neovascular age-related macular… #Ophthalmology #Eye #Ophthotwitter

Aqueous flare dynamics following penetrating, anterior lamellar, and endothelial corneal transplantation: Quantitative comparison and early complication detection Eye, Published online: 04 April 2026; doi:10.1038/s41433-026-04441-0Aqueous flare dynamics following penetrating, anterior lamellar, and endothelial corneal transplantation: Quantitative comparison and early complication detection

Ophthopedia Update: Aqueous flare dynamics following penetrating, anterior lamellar, and endothelial corneal transplantation: Quantitative comparison and early complication detection: Eye, Published online: 04 April 2026; doi:10.1038/s41433-026-04441-0Aqueous… #Ophthalmology #Eye #Ophthotwitter

Macular and retinal manifestations following COVID-19 vaccinations: a 2025 update systematic review and meta-analysis Eye, Published online: 04 April 2026; doi:10.1038/s41433-026-04324-4Macular and retinal manifestations following COVID-19 vaccinations: a 2025 update systematic review and meta-analysis

Ophthopedia Update: Macular and retinal manifestations following COVID-19 vaccinations: a 2025 update systematic review and meta-analysis: Eye, Published online: 04 April 2026; doi:10.1038/s41433-026-04324-4Macular and retinal manifestations following COVID-19… #Ophthalmology #Eye #Ophthotwitter

Comparative evaluation of large language model–based AI chatbots in solving ophthalmological clinical case vignettes Eye, Published online: 03 April 2026; doi:10.1038/s41433-026-04442-zComparative evaluation of large language model–based AI chatbots in solving ophthalmological clinical case vignettes

Ophthopedia Update: Comparative evaluation of large language model–based AI chatbots in solving ophthalmological clinical case vignettes: Eye, Published online: 03 April 2026; doi:10.1038/s41433-026-04442-zComparative evaluation of large language model–based AI… #Ophthalmology #Eye #Ophthotwitter

Can Gene Therapy Revolutionize Treatment of Neovascular Age-Related Macular Degeneration This systematic review and meta-analysis (PROSPERO: CRD42024619992) evaluated whether gene therapy provides safe and clinically meaningful efficacy for patients with neovascular age-related macular degeneration (nAMD). The clinical question addressed outcomes in patients with nAMD receiving gene therapy (primarily adeno-associated virus–based anti-VEGF constructs) compared with baseline or standard care contexts, focusing on visual acuity, anatomical response, treatment burden, and safety. Anti-VEGF intravitreal injections remain the current standard of care but require frequent administration and long-term adherence.

Ophthopedia Update: Can Gene Therapy Revolutionize Treatment of Neovascular Age-Related Macular Degeneration: This systematic review and meta-analysis (PROSPERO: CRD42024619992) evaluated whether gene therapy provides safe and clinically meaningful efficacy… #Ophthalmology #Ophthotwitter #Scicomm

Eligibility Criteria in RCTs of Anti-VEGF therapy for Diabetic Macular Edema: A Systematic Review Publication date: Available online 1 April 2026 Source: AJO International Author(s): Peter Elmegaard Junior, Vibeke Christensen, Maja Elise Sigaard Ravn, Lars Christian Boberg-Ans, Kristina Pfau, Rita Anjos, Rossella D’Aloisio, Damian Jaggi, Peter Kiraly, Lasse Jørgensen Cehofski, Jakob Grauslund, Mette Borg Madsen, Oliver Niels Klefter, Miklos Schneider, Yousif Subhi, Andreas Arnold-Vangsted

ICYMI: Ophthopedia Update: Eligibility Criteria in RCTs of Anti-VEGF therapy for Diabetic Macular Edema: A Systematic Review: Publication date: Available online 1 April 2026

Source: AJO International

Author(s): Peter Elmegaard Junior, Vibeke Christensen, Maja… #Ophthalmology #AJOInternational

Three-dimensional OCT Angiography Visualization of Vortex Vein Varix A 70-year-old woman with high myopia was referred for evaluation of a suspected choroidal mass in her left eye. The axial length of the left eye was 27.10 mm. Fundus photography showed a tessellated fundus without abnormal findings in the peripheral retina (A). Ultra-widefield OCT and angiography (BMizar, TowardPi Medical Technology Group Co, Ltd) of the superotemporal vortex vein demonstrated elevation of the overlying retina corresponding to a vortex vein varix (B, arrow), with localized thickening on the choroidal thickness map (C).

Ophthopedia Update: Three-dimensional OCT Angiography Visualization of Vortex Vein Varix: A 70-year-old woman with high myopia was referred for evaluation of a suspected choroidal mass in her left eye. The axial length of the left eye was 27.10 mm. Fundus… #Ophthalmology #ophthotwitter #eyecare

FDA approves extension of Eylea HD dosing intervals The FDA approved an extension of dosing intervals for Eylea HD in patients with diabetic macular edema and wet age-related macular degeneration, Regeneron Pharmaceuticals, Inc. announced. The approval, which extended the dosing intervals up to every 20 weeks, also includes an update to the Eylea HD (aflibercept 8 mg, Regeneron) label to include 2-year data from “the pivotal” PULSAR and PHOTON trials, according to a press release. “The potential for needing only two or three Eylea HD injections a year to manage certain retinal diseases is an exciting advance that could benefit

Ophthopedia Update: FDA approves extension of Eylea HD dosing intervals: The FDA approved an extension of dosing intervals for Eylea HD in patients with diabetic macular edema and wet age-related macular degeneration, Regeneron Pharmaceuticals, Inc. announced.
The… #ophthalmology #eye #eyenews

Tenecteplase Shows No Benefit Over Aspirin for Acute Central Retinal Artery Occlusion A phase 3 trial found no meaningful differences between tenecteplase and placebo treatment for acute central retinal artery occlusion, and some safety concerns were noted.

Ophthopedia Update: Tenecteplase Shows No Benefit Over Aspirin for Acute Central Retinal Artery Occlusion: A phase 3 trial found no meaningful differences between tenecteplase and placebo treatment for acute central retinal artery occlusion, and some safety concerns were noted. #Ophthalmology #News

Week in Review: Patient Education Chatbot, Compensation Disparities Among Ophthalmology Faculty A chatbot has the potential to provide text-to-speech patient education information on retinal detachment, and female ophthalmology faculty still earn less money than male faculty and have less representation in upper-rank positions.

Ophthopedia Update: Week in Review: Patient Education Chatbot, Compensation Disparities Among Ophthalmology Faculty: A chatbot has the potential to provide text-to-speech patient education information on retinal detachment, and female ophthalmology faculty still earn less… #Ophthalmology #News

👁️ New research highlights how donor & recipient factors shape corneal graft clarity after transplantation.
Using serial anterior segment OCT, the study reveals patterns that may improve monitoring, personalize care, and enhance outcomes.
#Ophthalmology #Cornea #OCT #EyeResearch

When is glue enough? Rethinking endpoints after cyanoacrylate treatment of corneal perforation Eye, Published online: 02 April 2026; doi:10.1038/s41433-026-04443-yWhen is glue enough? Rethinking endpoints after cyanoacrylate treatment of corneal perforation

Ophthopedia Update: When is glue enough? Rethinking endpoints after cyanoacrylate treatment of corneal perforation: Eye, Published online: 02 April 2026; doi:10.1038/s41433-026-04443-yWhen is glue enough? Rethinking endpoints after cyanoacrylate treatment of… #Ophthalmology #Eye #Ophthotwitter

K.C. Pharmaceuticals recalls more than 3 million eye drop bottles Editor’s note: This is a developing news story. Please check back soon for updates. K.C. Pharmaceuticals is recalling more than 3.1 million bottles of eye drops due to “lack of assurance of sterility,” according to the FDA. The eight affected products, totaling 3,111,072 individual units, have been distributed throughout the U.S. It is a class II recall, meaning the drops may cause temporary or reversible adverse effects, or have a low probability of causing severe adverse effects. The following products have been recalled:

Ophthopedia Update: K.C. Pharmaceuticals recalls more than 3 million eye drop bottles: Editor’s note: This is a developing news story. Please check back soon for updates.
K.C. Pharmaceuticals is recalling more than 3.1 million bottles of eye drops due to “lack of… #ophthalmology #eye #eyenews

Zenkuda superior to sham in phase 3 diabetic retinopathy study Zenkuda demonstrated superiority over sham in patients with diabetic retinopathy in the phase 3 GLOW2 study, according to a press release from Kodiak Sciences. In the confirmatory study, patients with proliferative diabetic retinopathy and mild diabetic macular edema and patients with moderately severe to severe diabetic retinopathy were randomly assigned to receive Zenkuda (tarcocimab tedromer) intravitreal injection (130 patients) or sham injection (125 patients), with dosing at baseline and at weeks 4, 8, 20 and 44. By the end of the study, all patients were on a 6-month dosing interval. At

Ophthopedia Update: Zenkuda superior to sham in phase 3 diabetic retinopathy study: Zenkuda demonstrated superiority over sham in patients with diabetic retinopathy in the phase 3 GLOW2 study, according to a press release from Kodiak Sciences.
In the confirmatory… #ophthalmology #eye #eyenews

High-volume clinic is inevitable. Burnout isn’t 👀

Shivam Chandra & Lisa Nijm share how to protect time and mental bandwidth

🔗 https://ow.ly/uIqL50YB8T8

#Ophthalmology #Burnout #MedLife

Patients want high-quality care, provider choice, affordability Click here to read the Cover Story, “Paralympian initiates advocacy for eye care.” A key factor to generate new patients for an eye care practice is patient word-of-mouth referrals. To maximize patient advocacy, we must generate patients who are satisfied with their care experience. In addition, happy patients also make for happier practice employees and doctors. Arguably, along with providing high-quality care, generating happy patients satisfied with their care experience is core to our purpose as physicians. To the classical saying “happy spouse, happy house,” we can add “happy patients,

Ophthopedia Update: Patients want high-quality care, provider choice, affordability: Click here to read the Cover Story, “Paralympian initiates advocacy for eye care.”
A key factor to generate new patients for an eye care practice is patient word-of-mouth referrals.
To… #ophthalmology #eye #eyenews

Brown recluse bite to the eyelid: a case report Brown recluse bite to the eyelid: a case report Affiliations & Notes aVanderbilt University School of Medicine, Nashville, Tennessee bVanderbilt Eye Institute, Nashville Tennessee Article Info Publication History: Received August 19, 2025; Revised January 8, 2026; Accepted February 16, 2026; Published online April 3, 2026 DOI: 10.1016/j.jaapos.2026.104820 External LinkAlso available on ScienceDirect External Link Copyright: © 2026 Published by Elsevier Inc. on behalf of the American Association for Pediatric Ophthalmology and Strabismus.

Ophthopedia Update: Brown recluse bite to the eyelid: a case report #Ophthalmology #Eye #Ophthotwitter

Lysinibacillus fusiformis Endophthalmitis after Intravitreal Anti-VEGF for Retinopathy of Prematurity A preterm infant with aggressive retinopathy of prematurity received bilateral intravitreal ranibizumab injections at an outside neonatal intensive care unit and developed endophthalmitis in the right eye with isolated vitreous exudates without anterior segment or retinal inflammation (A). Response was poor to systemic amphotericin and intravitreal vancomycin and ceftazidime. Pars plana vitrectomy cleared the exudates initially but they reoccurred. Vitreous biopsy identified Lysinibacillus fusiformis by MALDI-TOF (VITEK MS, bioMérieux), an environmental soil bacillus and opportunistic human pathogen.

Ophthopedia Update: Lysinibacillus fusiformis Endophthalmitis after Intravitreal Anti-VEGF for Retinopathy of Prematurity: A preterm infant with aggressive retinopathy of prematurity received bilateral intravitreal ranibizumab injections at an outside neonatal… #Ophthalmology #Retina #Ophthotwitter

Efficacy and Safety of Ranibizumab Biosimilars for Neovascular Age-Related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis Publication date: Available online 2 April 2026 Source: AJO International Author(s): Anas Alamoudi, Ahmed Alnabihi, Naif Almufarriji, Abdullah S AlQahtani

Ophthopedia Update: Efficacy and Safety of Ranibizumab Biosimilars for Neovascular Age-Related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis: Publication date: Available online 2 April 2026

Source: AJO International

Author(s): Anas… #Ophthalmology #AJOInternational

Performance of ChatGPT-5 in Producing Educational Questions for Ophthalmology Publication date: Available online 2 April 2026 Source: AJO International Author(s): Guy Marmur, Malachy Nemet, Adir Sommer, Aya Altarescu, Gil Ben-David, Slava Shor, Shirin Hamed Azzam, Elad Shvartz, Rima Diab, Yumna Busool Abu Eta, Achia Nemet, Daniel Bahir

Ophthopedia Update: Performance of ChatGPT-5 in Producing Educational Questions for Ophthalmology: Publication date: Available online 2 April 2026

Source: AJO International

Author(s): Guy Marmur, Malachy Nemet, Adir Sommer, Aya Altarescu, Gil Ben-David, Slava… #Ophthalmology #AJOInternational

Multimodal Large Language Models in Ophthalmology: Diagnostic Accuracy and the Risk of Metadata-Induced Confirmation Bias Publication date: Available online 2 April 2026 Source: AJO International Author(s): Cindy Tabuse, David Restrepo, Carolina Gracitelli, Fernando Korn Malerbi, Caio Regatieri, Luis Filipe Nakayama

Ophthopedia Update: Multimodal Large Language Models in Ophthalmology: Diagnostic Accuracy and the Risk of Metadata-Induced Confirmation Bias: Publication date: Available online 2 April 2026

Source: AJO International

Author(s): Cindy Tabuse, David Restrepo,… #Ophthalmology #AJOInternational

Diagnostic Utility of Corneal Parameters Measured with Pentacam Imaging in the Diagnosis of Early Keratoconus using real-world data: A Save Sight Keratoconus Registry study Publication date: Available online 31 March 2026 Source: AJO International Author(s): Amir Taher, Himal Kandel, Stephanie Watson

ICYMI: Ophthopedia Update: Diagnostic Utility of Corneal Parameters Measured with Pentacam Imaging in the Diagnosis of Early Keratoconus using real-world data: A Save Sight Keratoconus Registry study: Publication date: Available online 31 March 2026

Source: AJO… #Ophthalmology #AJOInternational

Delayed removal of a cat claw from the caruncle of a pediatric patient Main menu Articles Publish About Share More The content on this site is intended for healthcare professionals. All content on this site: Copyright © 2026 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.

Ophthopedia Update: Delayed removal of a cat claw from the caruncle of a pediatric patient #Ophthalmology #Eye #Ophthotwitter

CDC pauses lab testing for dozens of diseases The CDC has paused diagnostic testing for more than two dozen infectious diseases —including rabies and pox viruses — according to the agency’s website. HHS spokesman Andrew Nixon told Healio that the pause is temporary while the CDC “evaluates these assays as part of our routine review to uphold our commitment to high-quality laboratory testing.” Nixon said the department expects “some of these tests will be available through CDC labs again in the coming weeks,” but he did not specify which ones. J. Glenn Morris Jr., MD, MPH&TM, professor and former director of the Emerging Pathogens

Ophthopedia Update: CDC pauses lab testing for dozens of diseases: The CDC has paused diagnostic testing for more than two dozen infectious diseases —including rabies and pox viruses — according to the agency’s website.
HHS spokesman Andrew Nixon told Healio that the… #ophthalmology #eye #eyenews

ROP treatment receives orphan drug designation The FDA granted orphan drug designation to a triggering receptor expressed on myeloid cells 1 peptide inhibitor for the treatment of retinopathy of prematurity, according to a press release from SignaBlok. “Current therapeutic options (eye surgery, laser photocoagulation and eye injections of anti-VEGF drugs) are harmful, do not cure, have a high risk of serious complications and are often ineffective, suggesting an unmet need for new therapies,” Alexander B. Sigalov, PhD, president and founder of SignaBlok, told Healio. “SignaBlok addresses this urgent unmet need by introducing a novel,

Ophthopedia Update: ROP treatment receives orphan drug designation: The FDA granted orphan drug designation to a triggering receptor expressed on myeloid cells 1 peptide inhibitor for the treatment of retinopathy of prematurity, according to a press release from… #ophthalmology #eye #eyenews

UPFRONT Mystery Case #46: "Unmasking the Diagnosis of an Orbital Mass": Journal of Neuro-Ophthalmology
Article: bit.ly/JNO_UPFRONT_46 or on bit.ly/JNO_Home
#brain #eye #vision #research #Neurology #NeuroOphth #Ophthalmology @MontefioreNYC @EinsteinMed

After a Failed Penetrating Keratoplasty, Either DSAEK or DMEK Could Be an Option Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) appear to have similar outcomes when performed after a failed initial keratoplasty.

Ophthopedia Update: After a Failed Penetrating Keratoplasty, Either DSAEK or DMEK Could Be an Option: Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) appear to have similar outcomes when performed after a… #Ophthalmology #News

Glaukos helps patients, practices navigate Epioxa treatment Epioxa from Glaukos is the first epithelium-on corneal cross-linking treatment that has been FDA approved in the United States. While epi-on cross-linking has been common abroad for a number of years, Rajesh K. Rajpal, MD, said the procedure now has the potential to make a big difference for U.S. patients. “It’s a streamlined treatment because the UV light source is a higher-energy light combined with oxygen enrichment that enables the more efficient type II cross-linking. This helps overall for patients in terms of the amount of time their eyes are open and the amount of time they’re getting

Ophthopedia Update: Glaukos helps patients, practices navigate Epioxa treatment: Epioxa from Glaukos is the first epithelium-on corneal cross-linking treatment that has been FDA approved in the United States.
While epi-on cross-linking has been common abroad for a… #ophthalmology #eye #eyenews

Defining a standards framework for ophthalmology real-world data methodologies through an expert-led Delphi consensus Eye, Published online: 02 April 2026; doi:10.1038/s41433-026-04424-1Defining a standards framework for ophthalmology real-world data methodologies through an expert-led Delphi consensus

Ophthopedia Update: Defining a standards framework for ophthalmology real-world data methodologies through an expert-led Delphi consensus: Eye, Published online: 02 April 2026; doi:10.1038/s41433-026-04424-1Defining a standards framework for ophthalmology… #Ophthalmology #Eye #Ophthotwitter