IL-7 agonist #EfineptakinAlfa (NT-I7) reshapes the #TumorMicroenvironment, expanding T, B, DC, and stem-like CD8 T cells while inducing TLS-like aggregates enriched in PD-L1, suggesting synergy with #PD1blockade.

#OpenAccess: doi.org/10.1016/j.ge...

Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer

Scientists identify #IGF2BP1 as a driver of #ImmuneEvasion in C5 #OvarianCancer, suppressing IFN‑γ–IRF1–MHC‑I signaling and T‑cell infiltration; its inhibition restores #antitumor immunity and boosts #PD1blockade. @unihalle.bsky.social

#OpenAccess in #STTT: doi.org/10.1038/s413...