#EchinocysticAcid inhibits #BladderCancer by inducing #ferroptosis and suppressing proliferation, invasion, and migration via AKT1/GSK3β/β‑catenin inhibition, synergizing with #gemcitabine as a safe therapeutic option.

#OpenAccess: doi.org/10.1016/j.ge...

#Multiomics analysis reveals stage-specific targets in #TALL, highlighting CDK6, TUBA1A, TUBB and TYMS dysregulation across maturation stages; repurposed #mebendazole and #gemcitabine show selective #antileukemic activity.

#OpenAccess: doi.org/10.1016/j.ge...

Artios Reports Randomized Phase 2a Study of Low Dose Alnodesertib Plus Gemcitabine Achieves Primary Endpoint in Platinum-Resistant Ovarian Cancer - Artios Pharma Low dose alnodesertib plus gemcitabine met the primary endpoint of progression-free survival (PFS) versus gemcitabine alone in patients with platinum-resistant high-grade serous ovarian cancer Study p...

#ArtiosPharma #ovariancancer #PlatinumResistantOvarianCancer #oncology #GynaecologicalOncology #ovariancancermonth #Alnodesertib #Gemcitabine #biopharma #DDRmedicines #highgradeserousovariancarcinoma #HGSOC #ATRinhibitor #platinumresistantHGSOC #DDRpathways #DNAreplicationstress
zurl.co/XtxxD

SHR-1701 plus nab-paclitaxel and #gemcitabine show promising #antitumor activity with manageable safety in advanced #PancreaticCancer, while PD-L1 status and #biomarkers such as CA19-9 predict improved survival outcomes. @fudan-university.bsky.social

#STTT: doi.org/10.1038/s413...

A phase 1b/2 #ClinicalTrial evaluating SHR-1701 and nab-#Paclitaxel + #Gemcitabine showed promising anti-tumor activity and controllable safety in advanced or #Metastatic #PancreaticDuctalAdenocarcinoma. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1038/s413...

Does your Dr. make
you flip side to side
during treatment? A very unscientific poll #bladdercancer #bcgtreatment #gemcitabine #chemotherapy #adstiladrin

ZNF831, by inhibiting STAT3/Bcl2, promotes apoptosis & enhances chemosensitivity to #Capecitabine & #Gemcitabine, highlighting it as a novel tumor suppressor, potential #Biomarker & #TherapeuticTarget for #BreastCancer.

#OpenAccess: doi.org/10.1016/j.ge...

ASCO Publications

Gemcitabina intravesical + cetrelimab proporcionan mayor respuesta completa patológica, respuesta general y supervivencia libre de recurrencia al año en pacientes c/CA vejiga con invasión muscular #gemcitabine #cetrelimab #MIBC ascopubs.org/doi/abs/10.1...

October Issue: Conversion to Resection After Neoadjuvant #Gemcitabine , #Cisplatin , and #NabPaclitaxel for Borderline Resectable CCA: A Real-World Exploratory Analysis

https://rdcu.be/eMq0E

Same same but different - Nature Reviews Cancer In a recent study published in Nature, Liu, Wang, et al. investigate the mechanisms underlying cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of other nucleoside analogues, such as gemcitabine.

#ResearchHighlight 🚨
In a recent study, the Nussenzweig lab investigated the mechanisms underlying #cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of #gemcitabine.
📖⬇️

Mechanistic insights on how increased expression of Gal-3 in #TumorAssociatedFibroblasts enhances #Gemcitabine -resistance by suppressing #OxidativePhosphorylation in #PancreaticCancer cells. #PDAC #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

🚀 Key #UrothelialCancer abstracts from #ASCOGU!
📌 Abstract 661 – #Durvalumab (#MEDI4736) + neoadjuvant chemo (#Gemcitabine + #Cisplatin / #Carboplatin) in high-risk upper tract urothelial carcinoma.
📌 Abstract 667 – #Durvalumab + intravesical #Gemcitabine & #Docetaxel in #BCG-unresponsive NMIBC.

Nanoparticles for optimized cancer therapy Researchers have developed an effective new therapeutic approach against pancreatic cancer.

Scientists around Frauke Alves and colleagues at @yourUMG & @KITKarlsruhe developed a method to treat #PancreaticCancer, using so-called #nanoparticles. It transported the active substance #Gemcitabine in large quantities directly into the #tumor.
https://www.mpinat.mpg.de/4552645/pr_2320?c=2500106