Artios Reports Randomized Phase 2a Study of Low Dose Alnodesertib Plus Gemcitabine Achieves Primary Endpoint in Platinum-Resistant Ovarian Cancer - Artios Pharma Low dose alnodesertib plus gemcitabine met the primary endpoint of progression-free survival (PFS) versus gemcitabine alone in patients with platinum-resistant high-grade serous ovarian cancer Study p...

#ArtiosPharma #ovariancancer #PlatinumResistantOvarianCancer #oncology #GynaecologicalOncology #ovariancancermonth #Alnodesertib #Gemcitabine #biopharma #DDRmedicines #highgradeserousovariancarcinoma #HGSOC #ATRinhibitor #platinumresistantHGSOC #DDRpathways #DNAreplicationstress
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TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress Abstract. Oncogene activation in normal untransformed cells induces DNA replication stress and creates a dependency on DNA damage response (DDR) mechanisms

Oncogene activation causes #DNAreplicationstress, forcing cells to rely on #DNArepair. In #KRASdriven #PDAC, deletion of TRIP13 causes HR defects and cells become sensitive to #PARPinhibitors, making TRIP13 a new #therapeutictarget. Read the full article here: doi.org/10.1093/narc... #NARCancer