📣 NAR Cancer Call for Papers: Seeds of Cancer, Decades of Silence.
Submit work on early cancer initiation, ageing, environment, clonal evolution, genome maintenance and more before July 2026.
👉 academic.oup.com/narcancer/pa...
#NARCancer #CancerResearch #Genomics #Epigenetics

🔬 New study highlights a novel siRNA polypeptide #nanoparticle targeting TGF β1 and VEGFR2 to overcome ICI resistance in #melanoma. In mice, it cut tumor growth, improved survival, and reduced #metastasis. Read the full article here: doi.org/10.1093/narc...
#NARCAncer #Immunotherapy

⭐ Explore the NARCAN 5th Anniversary Symposium Collection!
🔬 Featuring exciting work on Polθ, HR, PARP inhibitors, emerging targets, and more!
Read here: lnkd.in/ezznFh2f
#NARCancer #DNARepair #CancerResearch #TherapeuticTargets #GenomicInstability

DNA repair helicases: from mechanistic understanding to therapeutic implications Abstract. The maintenance of genomic integrity is paramount for normal cell physiology and survival as well as avoidance of carcinogenesis. Cellular DNA is

📢 Read this timely review in #NARCancer! 🧬
Gueble and Menon highlight the critical role of #DNAhelicases in linking #DNAdamage recognition with #repair. The review includes a curated table of #clinicaltrials on #helicaseinhibitors.
Read it here: doi.org/10.1093/narc... @yalepress.bsky.social

THRESHOLD: a comprehensive transcriptomic analysis tool for evaluating gene saturation and impact in disease progression Abstract. Gene expression studies are fundamental in molecular biology, offering insights into development, disease progression, and therapeutic targets. T

📢Paper spotlight in NAR Cancer 🧬

A new study in #NARCancer introduces #THRESHOLD, a novel framework that measures gene expression “saturation” 📊—how consistently genes are expressed across cancer patients!

Read the full article here: doi.org/10.1093/narc...
#Transcriptomics #PrecisionOncology

SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression Abstract. SRSF2 (serine/arginine-rich splicing factor 2) is a critical regulator of pre-messenger RNA splicing, which also plays noncanonical functions in

New findings in #NARcancer ! Overexpressed SRSF2 drives #transcription & #replicationstress, causing DNA double-strand breaks. Read full article here: doi.org/10.1093/narc... #CancerResearch #LungCancer #DNArepair #Cancertherapy #openaccess @ugrenoblealpes.bsky.social

A new @NARCancer study shows ECM stiffness drives prostate cancer aggression 😱—with softer ECM boosting androgen response 💪. ECM isn’t just a structure; it also acts as a signal. Read the full article here: doi.org/10.1093/narc... #ProstateCancer #ECM #NARCancer #ATACseq #RNAseq @uniuef.bsky.social

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress Abstract. Oncogene activation in normal untransformed cells induces DNA replication stress and creates a dependency on DNA damage response (DDR) mechanisms

Oncogene activation causes #DNAreplicationstress, forcing cells to rely on #DNArepair. In #KRASdriven #PDAC, deletion of TRIP13 causes HR defects and cells become sensitive to #PARPinhibitors, making TRIP13 a new #therapeutictarget. Read the full article here: doi.org/10.1093/narc... #NARCancer

🧬 Don't miss the fourth and final session of NAR Cancer's 5th Anniversary Virtual Symposium!

🕛 Thursday 17 April at 12pm US Eastern time

👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol

Register here: lnkd.in/eRxxSxeu

#NARCancer #PARPInhibitors #DNARepair #GenomicStability

🧬 Don't miss the 4th session of NAR Cancer's 5th Anniversary Virtual Symposium!

🕛 Thursday 17 April - 12pm US Eastern time

👥 Featuring Dr Elise Fouquerel and Dr Robert W. Sobol

👉 Register here: lnkd.in/eRxxSxeu

#NARCancer #CancerResearch #DNADamage #DNARepair #GenomicStability #PARPInhibitors