Replicative gaps in DNA damage tolerance, genome instability, and cancer therapy Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions or difficult-to-replicate regions. This review delineates the pathways that generate, stabilize, and process these i...

Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.

#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors​​​​​​​​​​​​​​​​

www.cell.com/molecular-ce...

@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....

#DNAReplication
#GenomeStability
#MolecularBiology
#Biophysics
#SingleMolecule
#FluorescenceMicroscopy
#ForceSpectroscopy
#Replisome
#CancerResearch
#CellBiology
#MolecularMachines
#LiveScience
#ReplicationStress

SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression Abstract. SRSF2 (serine/arginine-rich splicing factor 2) is a critical regulator of pre-messenger RNA splicing, which also plays noncanonical functions in

New findings in #NARcancer ! Overexpressed SRSF2 drives #transcription & #replicationstress, causing DNA double-strand breaks. Read full article here: doi.org/10.1093/narc... #CancerResearch #LungCancer #DNArepair #Cancertherapy #openaccess @ugrenoblealpes.bsky.social

Redirecting

🚀 Thrilled to share our latest review: "Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance"

👉 doi.org/10.1016/j.mo...

#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil

Just as the heart is essential for life, TopBP1 is crucial for cell survival.

Cells need nuclear actin to relocate harmful DNA damage to safe areas.

IGH - MPL France

#valentinesday #PhDstudent #cancer #dnadamage #dnarepair #replicationstress #nuclearactin #condensates #cancerresearch

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal Nature Cell Biology - Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the...

as in @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING.
@manorlaboratory, @salkinstitute
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rdcu.be/dyV6K