Tap, tap, tap...it's been a minute, but I am at #ASB2026 and giving a talk this afternoon and have 3 students presenting posters. Check us out if you like learning about how tardigrades survive DNA damaging events. #tardigrades #Radiotolerance #DNAdamage

Learn about the #DNAdamage response in #CellPhysiology and diseases in the eponymous EMBO Workshop in #Sounio, #Greece, 12–16 October 2026.

Deadline: 17 May 2026

https://meetings.embo.org/event/26-dna-damage
#EMBODNADamageResponse #genesky #LifeSciences #research #meeting #EMBOevents 🧪

This review explores the dual role of #Rloops—three-strand nucleic acid structures that regulate genes yet threaten #GenomeStability—highlighting their impact on #DNAdamage and repair as a promising avenue for therapeutic innovation.

#OpenAccess: doi.org/10.1016/j.ge...

Follow @biohackingpathway for more

#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

DNA in our cells is often damaged by radiation and chemicals. If this damage is not repaired, mutations can occur, and diseases like cancer may develop. DNA repair systems are therefore essential for genome stability.
#DNADamage #Genetics
@pathsci2baldock.bsky.social
doi.org/10.1101/2025...

Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma

In this study, the researchers spotlight the #Antitumor potential of variant 7 among synthesized pyrrolidone compounds in #DLBCL cell lines, which induces #DNAdamage, #Inflammatory responses, #CellCycle arrest, & #Apoptosis. #medsky

To read: doi.org/10.1007/s115...

Anti-inflammatory and DNA Repair Effects of Astragaloside IV on PC12 Cells Damaged by Lipopolysaccharide

This study highlights #AstragalosideIV as a potent #Neuroprotective agent reversing LPS-induced #DNAdamage in PC12 cells by mitigating #DNAdamage, downregulating key #Inflammatory mediators, and inhibiting the IL-17 signaling pathway.

Read: doi.org/10.1007/s115...

#Research
Matricellular protein #SMOC2 safeguards tubular integrity in acute #kidney #injury via integrin β3-dependent inhibition of #CCND1-#CDK4/6 axis doi.org/10.1186/s435...

#CellCycleArrest #DNAdamage #RenalFibrosis

Follow @biohackingpathway for more

#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

Excited to share our latest study in Nature Communications ✨

We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track.

Paper: www.nature.com/articles/s41...

#Genomics #DNADamage #CellBiology

Targeting Genome Stability to Mitigate Human Aging and Disease - PubMed The maintenance of a stable genome requires constant repair. Congenital DNA repair defects lead to cancer susceptibility and progeroid (premature aging-like) syndromes. Even with intact repair, DNA lesions accumulate in aging organisms, leading to replication and transcription stress and age-depende …

🧬Your DNA is a fragile blueprint, gathering thousands of tiny "bruises" daily that whisper the story of aging. By awakening our inner "master regulators," science is finding ways to heal these marks and protect our life's vitality.
pubmed.ncbi.nlm.nih.gov/41086257/

#DNADamage, #DNARepair

RA-risk synovium exhibits DNA damage coupled with impaired DNA repair in fibroblasts - PubMed Our findings reveal persistent DNA damage in the preclinical phase of RA in both synovial tissue and fibroblasts, suggesting a role in disease progression. The partial restoration of DNA repair in synovial fibroblasts by senolytic treatment highlights its potential therapeutic target for preventativ …

The Silent Fissures

Tiny cracks appear in our genetic code long before the first ache of arthritis is ever felt. By mending these silent whispers early, we may stop the storm before it ever truly begins.

pubmed.ncbi.nlm.nih.gov/41571322/

#MolecularBiology, #DNADamage, #DNARepair

IGF2BP1 drives #MultipleMyeloma with 1q gain by stabilizing CDC5L mRNA via an m6A-dependent mechanism to regulate #DNAdamage response, highlighting the IGF2BP1-CDC5L axis as a key #TherapeuticTarget. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

The HeatDDR doctoral network training school in full swing @iebcas.bsky.social @pecinka-grp.bsky.social @zeiss-microscopy.bsky.social #microscopy #DNAdamage

This review highlights #Chk2 as a regulator of #DNAdamage responses, #autophagy, and #homeostasis, linking its dysregulation to digestive‑system #tumorigenesis and therapy resistance, and positioning it as a promising #anticancer target.

#OpenAccess: doi.org/10.1016/j.ge...

Join an upcoming webinar from Epigenome Technologies and EpiCypher, Inc. to learn how Paired-Damage-seq can reveal cell-type-specific DNA damage patterns and provide new insights into disease mechanisms!

January 29 | 10:00 AM PST

Register here: lnkd.in/eM_dv3yR

#Epigenetics #DNADamage

Epigenetics Update - Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer bit.ly/3NUCrtY

Rami I. Aqeilan reporting in Sci Adv

#Epigenetics #Superenhancers #Cancer #DNAdamage
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Discover the breakthrough at epigenometech.com

The Echo of Stars
Heavy ions leave deep scars in our DNA, but the cell responds as one unified world. In high alert, it mends distant sparks faster through a synchronized dance of survival.

pubmed.ncbi.nlm.nih.gov/41513727/

#MolecularBiology, #DNADamage, #DNARepair

Whole-body p21 transgenic🐭
#SkeletalMuscle atrophy fibrosis
⏬Treadmill Grip strength
SkM transcriptomic #Senescence #SASP
⏬OXPHOS
⏫myonuclei & interstitial cell #DNADamage

p21 OE does Not increase p16 in SkM

Nathan LeBrasseur lab #MolMetab 2023
www.sciencedirect.com/science/arti...

Naked mole-rats are one of the most fascinating wee beasties around! Read all about them in a recent blog I wrote for @epigenometech.bsky.social!

#Epigenetics #Blogs #NakedMoleRats #Aging #DNADamage

🏆 Great news!

The DNA Damage & Genome Instability team led by Vincent Pagès (CNRS) has secured ANR funding to study DNA damage tolerance, with Joe Loparo (Harvard Med) and Pauline Dupaigne (IGR), exploring how cells choose faithful vs mutagenic repair pathways 🧬

#DNADamage #ANR #CNRS

Join an upcoming webinar from Epigenome Technologies and @epicypher.bsky.social to learn how Paired-Damage-seq can reveal cell-type-specific DNA damage patterns and provide new insights into disease mechanisms!

January 29 | 10:00 AM PST

Register here: lnkd.in/eM_dv3yR

#Epigenetics #DNADamage

Epigenetic consequences of DNA damage DNA damage is not only a threat to genome integrity but also a driver of epigenetic regulation. This review highlights how oxidative lesions, R-loops, telomere damage, double-strand breaks, and PARP s...

Epigenetics Review - Epigenetic consequences of DNA damage bit.ly/45QCPjh

Tanya T. Paull (University of Texas) and Patricia L. Opresko (University of Pittsburgh) reported in Mol Cell

#Epigenetics #Review #DNADamage
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Gain deeper insights into gene regulation; epigenometech.com

🧬Aging starts at the molecular level.

Join the global dialogue at Global Longevity Federation GLF 2026

📍 Rome, Italy
🗓 Mar 23–24th 2026

🔗 longevityfederation.com

#Longevity #AgingBiology #DNADamage #DNARepair #Mitochondria #Epigenetics #HealthyAging #GLF2026

#radiation #cellradiation #iphone #smartphone #celldamage #DNAdamage #cancer #healthrisk

DNA Damage-driven Inflammatory Cytokines: Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

This comprehensive review explores the interplay between the #DNADamage response and #CytokineSignaling in #Tumors, highlighting their dual #Immunoregulatory roles and therapeutic implications. #medsky
Read more: link.springer.com/article/10.1...

Join an upcoming webinar from Epigenome Technologies and @epicypher.bsky.social to learn how Paired-Damage-seq can reveal cell-type-specific DNA damage patterns and provide new insights into disease mechanisms!

January 29 | 10:00 AM PST

Register here: lnkd.in/eM_dv3yR

#Epigenetics #DNADamage

The chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage Abstract. The SNF2 family chromatin remodeler HELLS has emerged as an important regulator of cell proliferation, genome stability, and several cancer pathw

HELLS shields cancer DNA by remodeling chromatin.
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨

academic.oup.com/nar/article/...

#DNADamage, #DNARepair

Pervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase - PubMed F-box proteins are the substrate recognition modules of the SCF (SKP1-Cullin-F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, the DNA damage response, and glioma stem ce …

FBXO42 keeps PP4 phosphatase activity under control. In a new paper, FBXO42 loss boosts PP4R2-dependent effects and increases IR sensitivity.

Colony survival in Fig 1E/5B was quantified by imaging + counting adherent colonies with #GelCount.

#DNADamage #CellBiology #Oncology

Follow @biohackingpathway for more

#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging