Prostaglandin E2-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma
PTGES-induced tumor-derived prostaglandin E2-driven dedifferentiation of Schwann cells drives perineural invasion in #PDAC, highlighting the PTGES-SC axis as a potential #TherapeuticTarget to prevent neural tumor spread. @tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
Activation of Nerve Growth Factor signaling limits the response to lenvatinib in hepatocellular carcinoma
Activation of nerve growth factor signaling promotes #Lenvatinib resistance in #HepatocellularCarcinoma, highlighting the NGF/TrkA pathway as a potential #TherapeuticTarget to enhance treatment efficacy. @fudan-university.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
Acyl-CoA-binding protein (ACBP): a poor-prognosis biomarker in sepsis and a target for disease mitigation
Elevated ACBP serves as a poor-prognosis biomarker in sepsis, driving inflammation & #OrganDysfunction, while its inhibition improves immune function & survival, positioning it as a promising #TherapeuticTarget. @sorbonne-universite.fr
#STTT #OpenAccess: doi.org/10.1038/s413...
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation
m6A-modified circArhgap26 exerts a #Cardioprotective effect against #Ischemia–#Reperfusion injury by inhibiting the DHHC5-mediated plakophilin-1 palmitoylation, highlighting it as a potential #Biomarker #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
cGMP–PKG signaling attenuates #AorticValveCalcification by activating ULK1-mediated #Autophagy and inhibiting #Osteogenic differentiation, suggesting a promising #TherapeuticTarget against calcific #AorticValveDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Ubiquitin-mediated stabilization of KDM5B promotes #Chemoresistance in #OvarianCancer by repressing DUSP4 and activating MAPK signaling, highlighting the KDM5B/DUSP4 axis as a #TherapeuticTarget for overcoming #Cisplatin resistance.
#STTT #OpenAccess: doi.org/10.1038/s413...
BMP4-mediated OPC–microglia crosstalk enhances Smad1/5/8–TREM2-driven microglial #Neuroprotection and reduces amyloid pathology, offering a promising #TherapeuticTarget in #AlzheimersDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Fibrinogen–Bmal1 signaling preserves VSMC contractility and limits #AorticDissection progression, offering a promising #TherapeuticTarget to improve vascular stability and patient outcomes.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study reveals that the SREBP-2 C-terminal fragment noncanonically drives IRAK1-dependent #Apoptosis, identifying a novel metabolic-apoptotic axis and a potential #TherapeuticTarget for #Sepsis-induced #Inflammation.
#OpenAccess: doi.org/10.1038/s413...
This #STTT study reveals that the Spi-1 #ProtoOncogene regulates mRNA hypertranscription to drive malignant progression in #HNSCC, offering a novel #TherapeuticTarget for hypertranscriptional HNSCC subtypes.
#OpenAccess: doi.org/10.1038/s413...
m6A-modified circArhgap26 attenuates cardiac I/R injury by suppressing plakophilin-1 palmitoylation, maintaining desmosome integrity and #Cardiomyocyte survival, offering a novel #TherapeuticTarget in #MyocardialInjury.
#STTT #OpenAccess: doi.org/10.1038/s413...
Drs. Sang Jun Han, D. Lonard et al are building the case for #SRC3 as a promising #therapeuticTarget for next-generation #cancer #immunotherapy. #Oncoimmunology @tandfonline.bsky.social @bcmhouston.bsky.social #BCMCancerCenter #HotTumor #ColdTumor blogs.bcm.edu/2026/03/26/f...
A phase I #ClinicalTrial evaluating the efficacy & safety of IBI351 monotherapy in Chinese patients with KRASG12C-mutated #Metastatic #ColorectalCancer shows a manageable safety profile. highlighting its potential as a #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
Prenatal prednisone exposure promotes #MASLD in offspring via #GR-HDAC3-mediated #Serpina3c suppression, activating the #Chymase-AngII-AT1R axis to disrupt lipid metabolism, marking #Serpina3c as a critical #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
Enhancing KLF15 expression in cardiomyocytes via a dCas9VPR-mediated transcriptional activation system prevents pathological remodeling and #Fibrosis, thereby establishing it as a critical regulator and #TherapeuticTarget in #HeartFailure.
#STTT #OpenAccess: doi.org/10.1038/s413...
Thromboxane A2 receptor activation in dendritic cells protects against #Sepsis by inhibiting S100a8/a9- mediated neutrophil infiltration and #SystemicInflammation, underscoring its potential as a #TherapeuticTarget.
#OpenAccess: doi.org/10.1038/s413...
GPR54 promotes progression & #MetabolicReprogramming in #NSCLC by enhancing dopa decarboxylase expression via the Gαq/11/PI3K/AKT/mTOR signaling pathway, underscoring its potential as both a #Biomarker & #TherapeuticTarget.
#OpenAccess: doi.org/10.1038/s413...
This #STTT study reveals that cholesterol interacts with the spike protein's palmitoylated C-rich region to enhance #SARSCoV2 docking and fusion, highlighting the interaction as a potent #TherapeuticTarget.
#OpenAccess: doi.org/10.1038/s413...
This study identified PDCD2 as a prognostic #Biomarker in #Glioma, showing that its overexpression promotes tumor progression and correlates with malignancy & poor survival, marking it as a potential #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
This review elucidates the regulatory role of #m6A modification in #PCD pathways, highlighting its influence on #CardiovascularDisease progression and its emerging potential as novel diagnostic and #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
This study identifies PTHrP1-34 from bronchial epithelial cells as a driver of #IdiopathicPulmonaryFibrosis, providing mechanistic insights that establish it as a critical #TherapeuticTarget for pulmonary intervention.
#STTT #OpenAccess: doi.org/10.1038/s413...
Reviewing the role of Nrf2 as a critical mediator of #Chemoradiotherapy resistance in #Osteosarcoma, the mechanisms underlying #OxidativeStress-mediated treatment evasion, and its potential as a #TherapeuticTarget in #BoneCancer treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#Microbiota-derived deoxycholic acid reprograms #AlveolarMacrophages via TGR5-PKA-STAT3 signaling to suppress pro-#Inflammatory cytokine production, offering a novel #TherapeuticTarget for treating #AcuteLungInjury.
#STTT #OpenAccess: doi.org/10.1038/s413...
This #STTT study reveals that #ExtracellularVesicle-derived #miRNA1825p induces an #Immunosuppressive macrophage phenotype in #PancreaticCancer, identifying a key mechanism of #ImmuneEvasion and a novel #TherapeuticTarget. #Medsky
#OpenAccess: doi.org/10.1038/s413...
Using #Multiomics and #ChIPseq, this #STTT study identified #MAPK14 as a central driver of #AbdominalAorticAneurysm that promotes #VSMC degeneration, suggesting the VSMC-MAPK14 axis as a potent #TherapeuticTarget to mitigate #AAA. #Medsky
#OpenAccess: doi.org/10.1038/s413...
This review describes the role of the transcription factor SOX4 in #LiverDisease & #HCC progression, highlighting it as a promising #TherapeuticTarget to modulate #Fibrogenesis and overcome #DrugResistance.
#OpenAccess: doi.org/10.1016/j.ge...
Serpina3c mitigates prenatal prednisone exposure-induced #MASLD susceptibility in offspring by modulating hepatic lipid metabolism & inflammatory pathways, highlighting it as a #TherapeuticTarget to reverse adverse #MetabolicProgramming. #Medsky
#OpenAccess: doi.org/10.1038/s413...
This study shows that EBNA1 induces ADAR1-driven resistance to #Immunotherapy by suppressing dsRNA-mediated innate immune signaling, identifying a novel #TherapeuticTarget for EBV-positive malignancies.
#STTT #OpenAccess: doi.org/10.1038/s413...
This #STTT study shows that PKCη promotes #BreastCancer #Metastasis by negatively regulating the Hippo pathway and stabilizing YAP, highlighting it as a potential #TherapeuticTarget in aggressive #TNBC.
#OpenAccess: doi.org/10.1038/s413...
High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1
High hydrostatic pressure exacerbates #BladderFibrosis by activating the mechanosensitive ion channel #Piezo1, thereby positioning Piezo1 as a potential #TherapeuticTarget for #BladderOutletObstruction.
Read more here: doi.org/10.1007/s115...
