High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1

High hydrostatic pressure exacerbates #BladderFibrosis by activating the mechanosensitive ion channel #Piezo1, thereby positioning Piezo1 as a potential #TherapeuticTarget for #BladderOutletObstruction.

Read more here: doi.org/10.1007/s115...

BOO‑associated #BladderFibrosis is driven by #EMT‑linked cytoskeletal remodeling via the TGF‑β/Cdc42/Cdc42ep1/F‑actin/Fibronectin axis; #Cdc42 inhibition suppresses #fibrosis, highlighting cytoskeletal regulators as therapeutic targets.

#OpenAccess: doi.org/10.1016/j.ge...

High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1

This study reveals that #Highhydrostaticpressure may exacerbate #BladderFibrosis through the activation of #Piezo1, which may serve as a potential therapeutic target for mitigating bladder fibrosis associated with #BladderOutletObstruction. #medsky

#MostDownloaded: link.springer.com/article/10.1...