Using #Multiomics and #ChIPseq, this #STTT study identified #MAPK14 as a central driver of #AbdominalAorticAneurysm that promotes #VSMC degeneration, suggesting the VSMC-MAPK14 axis as a potent #TherapeuticTarget to mitigate #AAA. #Medsky
#OpenAccess: doi.org/10.1038/s413...
Research Progress on the Pathogenesis and Treatment of Neoatherosclerosis
This review defines #neoatherosclerosis as a distinct in-stent pathology driven by oxidized lipids and #VSMC foam cells, stressing endothelial injury, #inflammation, and need for strategies beyond #LDL reduction to prevent #restenosis. @2024_HUST #stent
Read: doi.org/10.1007/s115...
Had an amazing time in Rio last week for the WC on Alternatives and Animal Use in Life Science!! Learnt so much about minimizing variability in our research.
A big thank you to @MAWA for funding my attendance to speak about our @victorchang.edu.au work on animal-free #iPSC #VSMC differentiation
We also find that using scCLEAN allows improved resolution for cellular biologic processes. This includes #vascular biology where nuanced #vsmc heterogeneity can be seen whereas traditional scRNAseq analysis would not. @tulanemedicine.bsky.social @tulaneu.bsky.social @scripps.edu
ACLY upregulation in coronary & pulmonary arteries fuels #VSMC proliferation in vascular diseases. Inhibition curbs remodeling, highlighting potential therapeutic leverage. #Cardiology #Innovation PMID:39661707, Sci Transl Med 2024
VSMC-Neubau in Singapur: 7,8 Mrd.-USD-Chipfabrik von NXP und VIS feiert ersten Spatenstich #semiconductor #nxp #vis #vsmc
